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Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes

Samelo, Jaime et al · American Chemical Society · 2017

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Author / responsible party
Samelo, Jaime et al
Publisher
American Chemical Society
Year
2017
ISSN
6863-6869
ISSN
6863-6869
Language
English

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A protocol is developed to allow the accurate characterization of partition to lipid bilayers for solutes with low affinity, using isothermal titration calorimetry. The methodology proposed is suitable for studies using complex membranes, such as intact biomembranes or whole cells. In the method developed, the association is characterized at increasing solute concentrations. This allows the characterization of solute partition into unperturbed membranes, as well as effects induced by high solute concentrations. Most druglike molecules are expected to interact with lowto-moderate affinity with relevant cell membranes. This is due to both the need for a relatively high aqueous solubility of the drug and the poor binding properties of the cell membranes. The methodology is applied to characterize the interaction of antibiotic Rifampicin with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and with lipid bilayers representative of bacterial membranes. Fil: Samelo, Jaime. CQC-Biological Chemistry Group; Portugal Fil: Mora, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina

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APA 7

Samelo, J. E. A. (2017). Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes. http://hdl.handle.net/11336/65828

MLA

Samelo, Jaime et al. "Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes." 2017. http://hdl.handle.net/11336/65828.

Chicago

Samelo, Jaime et al. 2017. "Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes.". http://hdl.handle.net/11336/65828.

Harvard

Samelo, J. E. A. 2017, Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes, American Chemical Society, available at: http://hdl.handle.net/11336/65828 [Accessed 8 Aug. 2026].

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Title
Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes
Author / contributors
Samelo, Jaime et al
Publisher
American Chemical Society
Publication year
2017
ISSN
6863-6869
ISSN
6863-6869
Language
English

Subjects

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Partition of Amphiphilic Molecules; Lipid Bilayers; Isothermal Titration Calorimetry; Rifampicin; https://purl.org/becyt/ford/2.10; https://purl.org/becyt/ford/2
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