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Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion

Muzzio, Nicolás Eduardo et al · Wiley-VCH · 2019

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Author / responsible party
Muzzio, Nicolás Eduardo et al
Publisher
Wiley-VCH
Year
2019
ISSN
2196-7350
ISSN
2196-7350
Language
English

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Summary

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Polyelectrolyte multilayers (PEMs) based on biopolyelectrolytes are highly appealing for the surface engineering of biomaterials and the tuning of cell response and phenotypes for biomedical applications. However, cell adhesion is limited on biopolyelectrolyte PEMs. Thermal annealing provides a simple means to increase or decrease cell adhesion on PEMs. The work presented here aims to understand cellular interactions with annealed PEMs based on the adsorption and exchangeability of two model proteins: fibronectin (FN), an adhesion protein, and bovine serum albumin (BSA), a nonadhesion protein. Protein adsorption and exchangeability are studied on annealed poly‐l‐lysine (PLL)/sodium alginate (Alg) and chitosan (Chi)/hyaluronic acid (HA) PEMs using [131I] radiolabeled proteins and gamma counting. Upon annealing cell adhesion is enhanced on PLL/Alg multilayers and decreased on Chi/HA multilayers. For PLL/Alg PEMs, annealing increases adsorption of both FN and BSA and reduces exchangeability. For Chi/HA multilayers, annealing increases BSA adsorption but decreases FN deposition, accompanied by a greater exchangeability. Changes in topographic features of deposited proteins on annealed PLL/Alg hint on changes in the 3D structure of the proteins. Circular dichroism shows that FN retains a large β‐sheet contribution upon adsorption to both annealed and unannealed PLL/Alg PEMs, also suggesting changes in tertiary structure. Fil: Muzzio, Nicolás Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Centro de Investigacion Cooperativa En Biomateriales.; España Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina

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APA 7

Muzzio, N. E. E. A. (2019). Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion. http://hdl.handle.net/11336/118900

MLA

Muzzio, Nicolás Eduardo et al. "Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion." 2019. http://hdl.handle.net/11336/118900.

Chicago

Muzzio, Nicolás Eduardo et al. 2019. "Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion.". http://hdl.handle.net/11336/118900.

Harvard

Muzzio, N. E. E. A. 2019, Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion, Wiley-VCH, available at: http://hdl.handle.net/11336/118900 [Accessed 7 Aug. 2026].

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Resource details

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Title
Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion
Author / contributors
Muzzio, Nicolás Eduardo et al
Publisher
Wiley-VCH
Publication year
2019
ISSN
2196-7350
ISSN
2196-7350
Language
English

Subjects

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CELL ADHESION MODULATION; FIBRONECTIN; POLYELECTROLYTE MULTILAYER; PROTEIN ADSORPTION; THERMAL ANNEALING; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1
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