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Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report

Lin TK et al · Dove Medical Press · 2026

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Author / responsible party
Lin TK et al
Publisher
Dove Medical Press
Year
2026
ISSN
1179-1365
ISSN
1179-1365
Language
English

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Tsung-Kun Lin,1,2,* Chih-Feng Chang,3,* Gwo-Ping Jong4,5 1Department of Pharmacy, Tri-Service General Hospital, Taipei, Taiwan, Republic of China; 2School of Pharmacy, National Defense Medical University, Taipei, Taiwan, Republic of China; 3Division of Cardiology, Department of Internal Medicine, Taichung Armed Force General Hospital, Taichung, Taiwan, Republic of China; 4Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China; 5School of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China*These authors contributed equally to this workCorrespondence: Gwo-Ping Jong, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China, Email cgp8009@yahoo.com.twAbstract: Livedoid vasculitis is a vascular autoimmune disorder affecting the skin. It most commonly occurs in young women. The occurrence of this condition after the coronavirus 2019 (COVID-19) vaccination is rare. The available literature suggests limited use of exosomes in the treatment of livedoid vasculitis. We present the case of a 65-year-old Chinese man who developed livedoid vasculitis after COVID-19 vaccination. We posit that the etiology in this case may be either COVID-19 vaccine-induced immune stimulation or activation of the condition by a rare vaccine component. This case is unique, with no previously reported precedents. The patient was treated intravenously for 1 month with stem cell-derived exosome therapy, using stem cells derived from exfoliated human deciduous teeth. This resulted in improvement in the livedoid vasculitis, with no reemergence of symptoms. This case highlights the therapeutic benefits of exosome treatment for livedoid vasculitis after COVID-19 vaccination. However, large-scale studies are needed before this outcome can be generalized.Keywords: livedoid vasculitis, COVID-19 vaccination, exosomes, elderly, exfoliated human deciduous teeth

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APA 7

al, L. T. E. (2026). Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report. https://www.dovepress.com/exosome-therapy-for-livedoid-vasculitis-following-covid-19-vaccination-peer-reviewed-fulltext-article-DHPS

MLA

al, Lin TK et. "Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report." 2026. https://www.dovepress.com/exosome-therapy-for-livedoid-vasculitis-following-covid-19-vaccination-peer-reviewed-fulltext-article-DHPS.

Chicago

al, Lin TK et. 2026. "Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report.". https://www.dovepress.com/exosome-therapy-for-livedoid-vasculitis-following-covid-19-vaccination-peer-reviewed-fulltext-article-DHPS.

Harvard

al, L. T. E. 2026, Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report, Dove Medical Press, available at: https://www.dovepress.com/exosome-therapy-for-livedoid-vasculitis-following-covid-19-vaccination-peer-reviewed-fulltext-article-DHPS [Accessed 6 Aug. 2026].

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Title
Exosome Therapy for Livedoid Vasculitis Following COVID-19 Vaccination: A Case Report
Author / contributors
Lin TK et al
Publisher
Dove Medical Press
Publication year
2026
ISSN
1179-1365
ISSN
1179-1365
Language
English

Subjects

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Livedoid vasculitis; COVID-19 vaccination; Exosomes; elderly; exfoliated human deciduous teeth.
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