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Glycan-targeted PEGylation for selective modification of proteins

Giorgi, María Eugenia et al · Elsevier · 2019

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Giorgi, María Eugenia et al
Publisher
Elsevier
Year
2019
Language
English

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Protein therapeutic agents frequently have short half-life in circulation due to their filtration by kidney, the action of proteolytic enzymes, the recognition by the immune system or the generation of neutralizing antibodies. To overcome these short comings, covalent modification with polyethylene glycol (PEG) has been widely applied. Among the numerous techniques developed for the introduction of the PEG chain, PEGylation at the carbohydrate moiety has the advantage of being site-selective, generating functional proteins with increased bioavailability. In this chapter we discuss different methodologies and applications of glycan-PEGylation, including glycoPEGylation and PEGylation of native glycoproteins, in particular coagulation factors used for treatment of hemophilia that are currently in the market or in the clinical trial phase Fil: Giorgi, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina Fil: Agusti, Rosalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina

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APA 7

Giorgi, M. E. E. A. (2019). Glycan-targeted PEGylation for selective modification of proteins. Elsevier. http://hdl.handle.net/11336/132025

MLA

Giorgi, María Eugenia et al. Glycan-targeted PEGylation for selective modification of proteins. Elsevier, 2019. http://hdl.handle.net/11336/132025.

Chicago

Giorgi, María Eugenia et al. 2019. Glycan-targeted PEGylation for selective modification of proteins. Elsevier. http://hdl.handle.net/11336/132025.

Harvard

Giorgi, M. E. E. A. 2019, Glycan-targeted PEGylation for selective modification of proteins, Elsevier, available at: http://hdl.handle.net/11336/132025 [Accessed 6 Aug. 2026].

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Title
Glycan-targeted PEGylation for selective modification of proteins
Author / contributors
Giorgi, María Eugenia et al
Publisher
Elsevier
Publication year
2019
Language
English

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GLYCOPEGYLATION; POLYMER-PROTEIN-CONJUGATE; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1
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