News Help Institutional access
Back to results
Bibliographic record · Consultation and access
Artículo

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

Terreros Roncal, J. et al · American Association for the Advancement of Science · 2021

Open-access full text
Quick overview. Review the resource’s basic details, then access the content using the main button. This page shows only the information needed to identify, cite, and open the work.
Author / responsible party
Terreros Roncal, J. et al
Publisher
American Association for the Advancement of Science
Year
2021
ISSN
1106-1113
ISSN
1106-1113
Language
English

Resource access

Open the content from the main option or choose another available source.

CONICET Digital CONICET Digital OAI-PMH
Entrar por CONICET Digital
Main access

Open-access full text

Texto completo identificado como acceso abierto.
Open text

Summary

Descripción general del contenido del recurso.

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans. Fil: Terreros Roncal, J.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España Fil: Moreno Jiménez, E.P.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España

How to cite

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

Terreros Roncal, J. E. A. (2021). Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. http://hdl.handle.net/11336/151271

MLA

Terreros Roncal, J. et al. "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis." 2021. http://hdl.handle.net/11336/151271.

Chicago

Terreros Roncal, J. et al. 2021. "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis.". http://hdl.handle.net/11336/151271.

Harvard

Terreros Roncal, J. E. A. 2021, Impact of neurodegenerative diseases on human adult hippocampal neurogenesis, American Association for the Advancement of Science, available at: http://hdl.handle.net/11336/151271 [Accessed 9 Aug. 2026].

Share and print

Save the record, copy its permanent link, or print it as a PDF.

Export reference

You can export the record in common formats for use in a reference manager.

RIS BibTeX

Resource details

Bibliographic information to help confirm that this is the correct material.

Title
Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
Author / contributors
Terreros Roncal, J. et al
Publisher
American Association for the Advancement of Science
Publication year
2021
ISSN
1106-1113
ISSN
1106-1113
Language
English

Subjects

Explore related resources through these subjects.

HUMAN ADULT NEUROGENES; NEURODEGENERATIVE DISEASES; MICROGLIA; AGING; https://purl.org/becyt/ford/1.7; https://purl.org/becyt/ford/1
Copied