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Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss

Ahmadian Chashmi, Najmeh et al · Birkhauser Boston Inc · 2013

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Author / responsible party
Ahmadian Chashmi, Najmeh et al
Publisher
Birkhauser Boston Inc
Year
2013
ISSN
1054-2523
ISSN
1054-2523
Language
English

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Linum album is a herbaceous medicinal plant that contains some lignans with antiviral and anticancer properties such as podophyllotoxin (PTOX) and 6-methoxy podophyllotoxin (MPTOX). In this research, hairy root cultures of L. album were established by transformation with Agrobacterium rhizogenes strains LBA9402, A4, AR15834 and A. tumefaciens strain C58C1 (pRiA4). The presence of PTOX and MPTOX in the hairy roots was verified by ESI/MS in positive ion mode. MPTOX was confirmed and its enantiomer determined by nuclear magnetic resonance spectroscopy and circular dichroism spectroscopy, respectively. PTOX and MPTOX production was determined by HPLC, in different lines of hairy roots. The results showed that all obtained hairy root lines produced higher yield of lignans than mother plant roots. In addition, the lignans content in the roots derived from A. rhizogenes strain LBA9402 was higher than in those obtained from A. tumefaciens strain C58C1. Fil: Ahmadian Chashmi, Najmeh. Tarbiat Modares University; Irán Fil: Sharifi, Mozafar. Tarbiat Modares University; Irán

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APA 7

Ahmadian Chashmi, N. E. A. (2013). Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss. http://hdl.handle.net/11336/1934

MLA

Ahmadian Chashmi, Najmeh et al. "Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss." 2013. http://hdl.handle.net/11336/1934.

Chicago

Ahmadian Chashmi, Najmeh et al. 2013. "Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss.". http://hdl.handle.net/11336/1934.

Harvard

Ahmadian Chashmi, N. E. A. 2013, Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss, Birkhauser Boston Inc, available at: http://hdl.handle.net/11336/1934 [Accessed 10 Aug. 2026].

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Title
Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss
Author / contributors
Ahmadian Chashmi, Najmeh et al
Publisher
Birkhauser Boston Inc
Publication year
2013
ISSN
1054-2523
ISSN
1054-2523
Language
English

Subjects

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6-METHOXY PODOPHYLLOTOXIN (MPTOX); AGROBACTERIUM; HAIRY ROOTS; LINUM ALBUM; PODOPHYLLOTOXIN (PTOX); https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1; https://purl.org/becyt/ford/2.9; https://purl.org/becyt/ford/2; https://purl.org/becyt/ford/3.1; https://purl.org/becyt/ford/3
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