A longitudinal dataset of hypertensive osteoporotic fracture patients: treatments and long-term outcomes

Abstract Osteoporotic fractures (OPF) and hypertension frequently co-occur in older adults, yet comprehensive datasets integrating clinical, pharmacological, and longitudinal outcome data remain scarce. We describe a longitudinal dataset derived from the Osteoporotic Fracture Registration System at Kunshan Hospital, Jiangsu University, including patients aged ≥ 50 years hospitalized for OPF between 2017 and 2024. A total of 4,782 patients were initially registered. After applying predefined eligibility criteria, 4,325 patients were included in the final analytical cohort. The dataset integrates demographic, clinical, and pharmacologic variables with long-term outcomes on mortality and refracture through deterministic linkage with regional health and mortality registries. Longitudinal antihypertensive prescription records (n = 42,367) were linked via the Kunshan Municipal Health Data Integration Platform, enabling detailed characterization of medication exposure patterns over time. Technical validation, including survival analysis, propensity score methods, and risk prediction modeling, was conducted to assess internal consistency and illustrate potential applications. This structured and de-identified dataset provides a quality-checked resource to support future research in osteoporosis, cardiovascular comorbidity, multimorbidity, and real-world comparative effectiveness studies.