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Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress

Bartos, Mariana et al · Pergamon-Elsevier Science Ltd · 2018

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Author / responsible party
Bartos, Mariana et al
Publisher
Pergamon-Elsevier Science Ltd
Year
2018
ISSN
0890-6238
ISSN
0890-6238
Language
English

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Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects of oral exposure to low levels of F during the gestational and lactation periods, on the memory of adult female rat offspring. We also considered a possible underlying neurotoxic mechanism. Our results showed that this exposure reduced step-down latency in the inhibitory avoidance task, and decreased both mRNA expression of the α7 nicotinic receptor (nAChR) and catalase activity in hippocampus. Our data indicates that low F concentrations administrated during gestation and lactation decrease the memory of 90-day-old female offspring. This suggests that the mechanism might be connected with an α7 nAChR deficit in the hippocampus, induced by oxidative stress. Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina

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APA 7

Bartos, M. E. A. (2018). Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress. http://hdl.handle.net/11336/87729

MLA

Bartos, Mariana et al. "Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress." 2018. http://hdl.handle.net/11336/87729.

Chicago

Bartos, Mariana et al. 2018. "Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress.". http://hdl.handle.net/11336/87729.

Harvard

Bartos, M. E. A. 2018, Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress, Pergamon-Elsevier Science Ltd, available at: http://hdl.handle.net/11336/87729 [Accessed 8 Aug. 2026].

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Title
Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress
Author / contributors
Bartos, Mariana et al
Publisher
Pergamon-Elsevier Science Ltd
Publication year
2018
ISSN
0890-6238
ISSN
0890-6238
Language
English

Subjects

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DEVELOPMENT EXPOSURE; FLUORIDE; MEMORY; NICOTINIC RECEPTOR; OXIDATIVE STRESS; RAT OFFSPRING; https://purl.org/becyt/ford/3.1; https://purl.org/becyt/ford/3
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