Controle da hiperlipidemia em coelhos tratados com flavonóides e corantes naturais do urucum

Tendo em vista que a hiperlipidemia se constitui em fator de risco para o sistema cardiocirculatório, levando ao aparecimento da aterosclerose, o presente trabalho foi desenvolvido, objetivando o controle de lipídeos com os flavonóides luteolina e apigenina, bem como do corante natural do urucum, bixina 30% e bixina 95%, em coelhos hiperlipidemicos induzidos com triton. Decorridos 20 horas da aplicação o triton, foram administrados os compostos na dose de 10 mmol/Kg e, 24 horas após, dosados no soro dos animais, colesterol total, colesterol-HDL e triacilgliceróis. Os resultados mostram que os tratamentos foram eficazes em reduzir os níveis de colesterol total; a exceção de bixina 30%, mantiveram os níveis elevados de colesterol-HDL e a bixina 30% diminuiu significativamente os valores de triacilgliceróis. The hyperlipidaemia is a risk factor for the development of atherosclerosis in the cardiovascular system. The present work evaluated the effects of three compounds isolated from the urucum, the flavonoids luteolin and apigenin and the natural coloring bixin (30% and 95%), on the control of serum lipids in triton-induced hyperlipidaemic rabbits. After 20 hours triton 300mg/Kg weight was administered intraperitoneal(i.p.) the rabbits were injected ¡.p. with bixin 30%. bixiii 95%, luteolin or apigenin at the dose of 10 mmol/Kg weigth. 24 hours latter total cholesterol. cholesterol-HDL and triacylglycerols were dosed in the serum of the animals. The results showed that all compounds were effective in reducing the levels of total cholesterol. Except bixin 30% the treatments incresed the levels of cholesterol-HDL, notably apigenin by about three fold. Bixine 30% was the only treatment that reduced the levels of tracylglicerols. It may be suggested that these natural compounds may have beneficial effects in controlling serum lipids levels when used as flavoring or coloring of foods. Colegio de Farmacéuticos de la Provincia de Buenos Aires