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A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev; Luke G. Green; Valery V. Fokin; K. Barry Sharpless · Angewandte Chemie International Edition · 2002

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Author / responsible party
Vsevolod V. Rostovtsev; Luke G. Green; Valery V. Fokin; K. Barry Sharpless
Publisher
Angewandte Chemie International Edition
Year
2002
Language
English

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By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective copper(I)-catalyzed process (see scheme for an example). Supporting information for this article is available on the WWW under http://www.angewandte.org or from the author. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z19191_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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APA 7

Rostovtsev, V. V, Green, L. G, Fokin, V. V, & Sharpless, K. B. (2002). A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes. https://doi.org/10.1002/1521-3773(20020715)41:14<2596:aid-anie2596>3.0.co;2-4

MLA

Rostovtsev, Vsevolod V, et al. "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes." 2002. https://doi.org/10.1002/1521-3773(20020715)41:14<2596:aid-anie2596>3.0.co;2-4.

Chicago

Rostovtsev, Vsevolod V, Luke G. Green, Valery V. Fokin, and K. Barry Sharpless. 2002. "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes.". https://doi.org/10.1002/1521-3773(20020715)41:14<2596:aid-anie2596>3.0.co;2-4.

Harvard

Rostovtsev, V. V. et al. 2002, A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes, Angewandte Chemie International Edition, available at: https://doi.org/10.1002/1521-3773(20020715)41:14<2596:aid-anie2596>3.0.co;2-4 [Accessed 6 Aug. 2026].

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Title
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
Author / contributors
Vsevolod V. Rostovtsev; Luke G. Green; Valery V. Fokin; K. Barry Sharpless
Publisher
Angewandte Chemie International Edition
Publication year
2002
Language
English

Subjects

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Regioselectivity; Cycloaddition; Terminal (telecommunication); Copper; Chemistry; Catalysis; Combinatorial chemistry; Process (computing); Research article; Computer science; Organic chemistry; Operating system
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