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Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study

Ray, Debajyoti et al · SEDICI UNLP · 2009

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Author / responsible party
Ray, Debajyoti et al
Publisher
SEDICI UNLP
Year
2009
Language
English

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The present study aims at developing synthesized (PVA-co-PAA)/NaCl normal hydrogel(H), hydrogel microspheres(HM) and comparing the antihypertensive activity of Diltiazem hydrochloride(DL) from two formulations. The hydrogel microspheres were crosslinked by using glutaraldehyde-saturated toluene. The hydrogel showed more swelling in simulated intestinal fluid (SIF). (PVA-co-PAA)/NaCl HM formulation A1 showed comparatively higher entrapment (79%) and better control over DL release. In normotensive rats, HM formulation A1 found more effectively in reducing blood pressure to 40.1%. The experimental results demonstrated that (PVA-co-PAA)/NaCl HM had the greater potential than normal hydrogel to be used as a drug carrier. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Ray, D. E. A. (2009). Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study. http://sedici.unlp.edu.ar/handle/10915/7831

MLA

Ray, Debajyoti et al. "Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study." 2009. http://sedici.unlp.edu.ar/handle/10915/7831.

Chicago

Ray, Debajyoti et al. 2009. "Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study.". http://sedici.unlp.edu.ar/handle/10915/7831.

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Ray, D. E. A. 2009, Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7831 [Accessed 8 Aug. 2026].

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Title
Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
Author / contributors
Ray, Debajyoti et al
Publisher
SEDICI UNLP
Publication year
2009
Language
English

Subjects

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Farmacia; Farmacología; drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling; Medicamentos
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