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New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups

Nogueira, Nayane M. et al · SEDICI UNLP · 2010

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Author / responsible party
Nogueira, Nayane M. et al
Publisher
SEDICI UNLP
Year
2010
Language
English

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New rapid first-derivative spectrophotometric (UVDS) and a stability-indicating high performance liquid chromatographic (HPLC) methods were developed, validated and successfully applied in the analysis of loratadine (LT) in tablets and syrups. In the UVDS method, 0.1 M HCl was used as solvent. The measurements were made at 312.4 nm in the first order derivative spectra. The HPLC method was carried out on a RP-18 column with a mobile phase composed of methanol-water-tetrahydrofuran (50:30:20, v/v/v). UV detection was made at 247 nm. For HPLC methods the total analysis time was <3min, adequate for routine quality control of tablets and syrups containing loratadine. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Nogueira, N. M. E. A. (2010). New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups. http://sedici.unlp.edu.ar/handle/10915/7914

MLA

Nogueira, Nayane M. et al. "New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups." 2010. http://sedici.unlp.edu.ar/handle/10915/7914.

Chicago

Nogueira, Nayane M. et al. 2010. "New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups.". http://sedici.unlp.edu.ar/handle/10915/7914.

Harvard

Nogueira, N. M. E. A. 2010, New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7914 [Accessed 7 Aug. 2026].

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Resource details

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Title
New rapid Derivative spectrophotometric and chromatographic methods for assay of loratadine in tablets and syrups
Author / contributors
Nogueira, Nayane M. et al
Publisher
SEDICI UNLP
Publication year
2010
Language
English

Subjects

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Farmacia; Farmacología; assay methods; first-derivative spectrophotometry; liquid chromatography; loratadine; Cromatografía
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