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Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system

Chitneni, Mallikarjun et al · SEDICI UNLP · 2010

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Author / responsible party
Chitneni, Mallikarjun et al
Publisher
SEDICI UNLP
Year
2010
Language
English

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The self-microemulsifying drug delivery system (SMEDDS) was employed to improve the bioavailability of sulpiride, a drug which is poorly soluble. The mean droplet size and emulsification time of the test formulation used for in vivo study were 9.27 ± 2.02 nm and 87 ± 5 s, respectively. When compared with Reference (Dogmatil®), the test formulation exhibited faster in-vitro drug release rate. The Cmax and AUC values of the test formulation were significantly higher than those of Reference, with an enhancement of 210.64% in the extent of absorption in rabbits. In conclusion, SMEDDS could be a potential drug delivery system to enhance the bioavailability of sulpiride. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Chitneni, M. E. A. (2010). Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system. http://sedici.unlp.edu.ar/handle/10915/7941

MLA

Chitneni, Mallikarjun et al. "Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system." 2010. http://sedici.unlp.edu.ar/handle/10915/7941.

Chicago

Chitneni, Mallikarjun et al. 2010. "Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system.". http://sedici.unlp.edu.ar/handle/10915/7941.

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Chitneni, M. E. A. 2010, Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7941 [Accessed 8 Aug. 2026].

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Title
Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
Author / contributors
Chitneni, Mallikarjun et al
Publisher
SEDICI UNLP
Publication year
2010
Language
English

Subjects

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Farmacia; self-microemulsifying drug delivery system; sulpiride; bioavailability; Farmacología; Medicamentos; Disponibilidad biológica
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