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Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding

Man, Shuli et al · SEDICI UNLP · 2010

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Author / responsible party
Man, Shuli et al
Publisher
SEDICI UNLP
Year
2010
Language
English

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Oral administration to rats of Rhizoma Paridis saponins (RPS) from Paris polyphylla var. yunnanensis extracts have been found to show strong anti-tumor activity, but the effective constituents were not known. To detail the effective components in RPS, we investigated the serum pharmacochemistry after oral administration of RPS and detected eight kinds of Paridis saponins in the rat serum. Then we purposefully purified a mixture (PM) from RPS to further research. By comparison of tumor weight, spleen index, antitumor rate and numbers of metastases, PM showed a considerable activity as RPS. In conclusion, the serum pharmacochemistry can help us purposefully to separate and purify RPS and to obtain a potential antitumor agent which may be better than parent drugs. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Man, S. E. A. (2010). Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding. http://sedici.unlp.edu.ar/handle/10915/8048

MLA

Man, Shuli et al. "Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding." 2010. http://sedici.unlp.edu.ar/handle/10915/8048.

Chicago

Man, Shuli et al. 2010. "Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding.". http://sedici.unlp.edu.ar/handle/10915/8048.

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Man, S. E. A. 2010, Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8048 [Accessed 8 Aug. 2026].

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Title
Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
Author / contributors
Man, Shuli et al
Publisher
SEDICI UNLP
Publication year
2010
Language
English

Subjects

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Farmacia; anti-tumor effect; HPLC-MS; Paris polyphylla; serum pharmacochemistry; steroidal saponin
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