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Pharmacological basis for the medicinal use of Valeriana wallichii in constipation

Khan, Arif-ullah et al · SEDICI UNLP · 2011

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Author / responsible party
Khan, Arif-ullah et al
Publisher
SEDICI UNLP
Year
2011
Language
English

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Valeriana wallichii D.C. (Valerianaceae) is widely used in folk medicine for the treatment of hypo-motility disorder of the gut. The aim of the present study was to scientifically rationalize its usefulness in the constipation. The V. wallichii leaves crude extract, which tested positive for the presence of anthraquinones, flavonoids, saponins, sterols, tannins and terpenes caused concentration-dependent (3-10 mg/mL) contractile effect in isolated guinea-pig ileum. Pretreatment of tissues with atropine (1 μM) completely abolished the stimulatory effect of V. wallichii leaves crude extract, similar to that of acetylcholine. These results indicate that the spasmogenic effect of V. wallichii is mediated possibly through the activation of muscarinic receptors, which provides sound mechanistic background for its medicinal use in constipation. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Khan, A. U. E. A. (2011). Pharmacological basis for the medicinal use of Valeriana wallichii in constipation. http://sedici.unlp.edu.ar/handle/10915/8121

MLA

Khan, Arif-ullah et al. "Pharmacological basis for the medicinal use of Valeriana wallichii in constipation." 2011. http://sedici.unlp.edu.ar/handle/10915/8121.

Chicago

Khan, Arif-ullah et al. 2011. "Pharmacological basis for the medicinal use of Valeriana wallichii in constipation.". http://sedici.unlp.edu.ar/handle/10915/8121.

Harvard

Khan, A. U. E. A. 2011, Pharmacological basis for the medicinal use of Valeriana wallichii in constipation, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8121 [Accessed 8 Aug. 2026].

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Title
Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
Author / contributors
Khan, Arif-ullah et al
Publisher
SEDICI UNLP
Publication year
2011
Language
English

Subjects

Explore related resources through these subjects.

Farmacia; cholinergic; constipation; spasmogenic; Valeriana wallichii; Receptores Muscarínicos; Valeriana; Estreñimiento; Extractos Vegetales
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