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Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia)

Márquez, Diana M. et al · SEDICI UNLP · 2011

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Author / responsible party
Márquez, Diana M. et al
Publisher
SEDICI UNLP
Year
2011
Language
English

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Ethanol and dichloromethane extracts from the marine sponge Iotrochota birotulata collected in the Urabá Gulf (Colombia) were tested against three human tumor cellular lines, including lung (A- 549), colon (HT29) and breast (MDA-MB-231), at 1 µg/mL, 5 &microg/mL and 25 &microg/mL. The most bioactive extract (ethanol), was separated by flash column chromatography obtaining six fractions which biological activity was evaluated on the same cellular lines A-549, HT29 and MDA-MB-231, at 1&microg/mL, 5 &microg/mL and 25 &microg/mL. The bioassay results showed that both extracts and two of the fractions totally inhibited the growing of the cellular line A549 at 25 &microg/mL, while the most active fraction showed total inhibition of the growing of the three tumor cell lines on the three evaluated concentrations. The most active fraction was separated by reversed phase HPLC which allowed isolating and then characterizing by mono- and bidimensional NMR, a halogenated compound derived from the bromotyrosine. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Márquez, D. M. E. A. (2011). Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia). http://sedici.unlp.edu.ar/handle/10915/8152

MLA

Márquez, Diana M. et al. "Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia)." 2011. http://sedici.unlp.edu.ar/handle/10915/8152.

Chicago

Márquez, Diana M. et al. 2011. "Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia).". http://sedici.unlp.edu.ar/handle/10915/8152.

Harvard

Márquez, D. M. E. A. 2011, Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia), SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8152 [Accessed 7 Aug. 2026].

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Title
Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia)
Author / contributors
Márquez, Diana M. et al
Publisher
SEDICI UNLP
Publication year
2011
Language
English

Subjects

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Farmacia; bromotyrosine; Iotrochota birotulata; marine sponge; Extractos Vegetales; Línea Celular Tumoral; Técnicas y Procedimientos de Laboratorio
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