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Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior

Vechia, Débora D. et al · SEDICI UNLP · 2011

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Author / responsible party
Vechia, Débora D. et al
Publisher
SEDICI UNLP
Year
2011
Language
English

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Hydrophilic matrix tablets were developed with acyclovir (ACV), using hypromelose and polyethylene oxide (PEO) in different concentrations. Matrix tablets obtained in each formulation were evaluated to determine the weight variation, thickness, hardness, drug content, swelling and erosion and in vitro release. The swelling and erosion studies were influenced by pH value and polymer type. The ACV release under acid conditions occurred around 12 and 6 h for PEO and hypromelose matrices, respectively. The mechanism involved in drug release was characterized by anomalous behavior for all formulations, except in 0.1 N HCl where formulations containing hypromelose demonstrated a Super Case II kinetics. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Vechia, D. D. E. A. (2011). Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior. http://sedici.unlp.edu.ar/handle/10915/8166

MLA

Vechia, Débora D. et al. "Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior." 2011. http://sedici.unlp.edu.ar/handle/10915/8166.

Chicago

Vechia, Débora D. et al. 2011. "Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior.". http://sedici.unlp.edu.ar/handle/10915/8166.

Harvard

Vechia, D. D. E. A. 2011, Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8166 [Accessed 10 Aug. 2026].

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Resource details

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Title
Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
Author / contributors
Vechia, Débora D. et al
Publisher
SEDICI UNLP
Publication year
2011
Language
English

Subjects

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Farmacia; ACV; hypromelose; hydrophilic matrix tablets; POE; polymer gels
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