Stability of loratadine tablets in Argentina

Brevedan, Marta I. V. et al · SEDICI UNLP · 2011

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Brevedan, Marta I. V. et al

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SEDICI UNLP

Year

2011

Language

English

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Stability of loratadine formulations can be affected when the product is exposed to high temperature and humidity. In this study, chemical and in vitro dissolution stability of loratadine (10 mg) tablets available in Argentina were assessed. Drug content and dissolution profiles were determined according to USP29, at time zero, and after 3 and 6 months of storage under ICH accelerated aging conditions (40 °C, 75 % RH). Dissolution efficiency and assay values were compared, both by mathematical and statistical methods, to assess interchangeability and stability during aging. After 180 days, most formulations evaluated showed statistically significant changes in the active ingredient and in the dissolution behaviour. Only formulation K did not meet the assay acceptance criteria. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Brevedan, M. I. V. E. A. (2011). Stability of loratadine tablets in Argentina. http://sedici.unlp.edu.ar/handle/10915/8202

MLA

Brevedan, Marta I. V. et al. "Stability of loratadine tablets in Argentina." 2011. http://sedici.unlp.edu.ar/handle/10915/8202.

Chicago

Brevedan, Marta I. V. et al. 2011. "Stability of loratadine tablets in Argentina.". http://sedici.unlp.edu.ar/handle/10915/8202.

Harvard

Brevedan, M. I. V. E. A. 2011, Stability of loratadine tablets in Argentina, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8202 [Accessed 8 Aug. 2026].

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Title: Stability of loratadine tablets in Argentina

Author / contributors: Brevedan, Marta I. V. et al

Publisher: SEDICI UNLP

Publication year: 2011

Language: English

Subjects

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Farmacia; Estabilidad de Medicamentos; aging conditions; dissolution; loratadine; stability; tablets