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Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release

Aloorkar, Nagesh H. et al · SEDICI UNLP · 2011

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Author / responsible party
Aloorkar, Nagesh H. et al
Publisher
SEDICI UNLP
Year
2011
Language
English

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A novel polymer, chemically modified chitosan was synthesized by reacting with hydrochloride salt of 2-aminoethanoyl chloride. Formation of novel chemically modified chitosan was confirmed by FTIR and NMR spectroscopy and by thermal (DSC) and elemental analysis. Acute oral toxicity study was performed on modified chitosan to check its safety. Ibuprofen, paracetamol and diclofenac sodium tablets were compressed on a single punch tablet machine using the weight granulation method. The drug release was found to be delayed from the formulations containing chemically modified chitosan. Thus, it could be concluded that the change in the hydrophilic balance and the resultant change in the modulation of swelling of the polymer may retard the drug release from polymer matrices. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Aloorkar, N. H. E. A. (2011). Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release. http://sedici.unlp.edu.ar/handle/10915/8231

MLA

Aloorkar, Nagesh H. et al. "Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release." 2011. http://sedici.unlp.edu.ar/handle/10915/8231.

Chicago

Aloorkar, Nagesh H. et al. 2011. "Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release.". http://sedici.unlp.edu.ar/handle/10915/8231.

Harvard

Aloorkar, N. H. E. A. 2011, Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8231 [Accessed 7 Aug. 2026].

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Title
Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
Author / contributors
Aloorkar, Nagesh H. et al
Publisher
SEDICI UNLP
Publication year
2011
Language
English

Subjects

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Farmacia; acylation; 2-aminoethanoyl chloride; chitosan; drug release; Polisacáridos; Procesos Bioquímicos; Sistemas de Liberación de Medicamentos
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