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Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients

Ige, Pradum P. et al · SEDICI UNLP · 2011

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Author / responsible party
Ige, Pradum P. et al
Publisher
SEDICI UNLP
Year
2011
Language
English

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The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet granulation method with HPMC K200M and HPMC K100M in combination using Minipress and characterized by Fourier Transform Infra-Red spectroscopy, differential scanning calorimetry, x-ray diffraction, mucoadhesion, swelling, erosion and in vitro drug release. The optimized formulation F8 shows the 4 fold and F2 & F11 shows the 3 fold swelling. Mucoadhesion strength and ex-vivo retention time of F8 was found to have 128.47 grams and 9.23 h, respectively. The F2, F8 and F11 were proved to be an expandable GRDF and showed case II diffusion mechanism with optimum erosion. The in vitro drug release, mucoadhesion, swelling, erosion and ex-vivo retention time evidences were concluded that retention of tablets in stomach up to 14 h and sustained release of drug. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Ige, P. P. E. A. (2011). Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients. http://sedici.unlp.edu.ar/handle/10915/8270

MLA

Ige, Pradum P. et al. "Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients." 2011. http://sedici.unlp.edu.ar/handle/10915/8270.

Chicago

Ige, Pradum P. et al. 2011. "Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients.". http://sedici.unlp.edu.ar/handle/10915/8270.

Harvard

Ige, P. P. E. A. 2011, Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8270 [Accessed 7 Aug. 2026].

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Title
Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
Author / contributors
Ige, Pradum P. et al
Publisher
SEDICI UNLP
Publication year
2011
Language
English

Subjects

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Farmacia; gastric retention; hydroxy propyl methyl cellulose K200M; metformin HCl; swelling matrix tablets; type 2 diabetes mellitus; Enfermedades del Sistema Endocrino; Sistemas de Liberación de Medicamentos
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