The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy

The deposition of chlorhexidine base on thermosensitive N-isopropylacrylamide polymeric microparticles was assessed in this study using energy dispersive X-ray spectrometry (EDXS) in scanning electron microscopy (SEM) setting. Three different types of polymer were synthesized. The PN1 was a polymer with terminal anionic groups resulting from potassium persulphate initiator. The PN2 was synthesized with 2,2’-azobis(2-methylpropionamidine)dihydrochloride, what resulted in cationic amidine terminal groups. The PN3 had anionic terminals, however increased hydrophobicity was maintained with Ntert-butylacrylate functional groups. The thermosensitivity of the polymer-chlorhexidine complexes was confirmed by the turbidimetric assay. The deposition patterns, observed in/on the polymers give the assumption to develop the applications of evaluated polymers as factors influencing chlorhexidine release from the topical formulations. Colegio de Farmacéuticos de la Provincia de Buenos Aires