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Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres

Medeiros, Daniela C. de et al · SEDICI UNLP · 2011

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Author / responsible party
Medeiros, Daniela C. de et al
Publisher
SEDICI UNLP
Year
2011
Language
English

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Microspheres were prepared using the emulsion/solvent evaporation method with the aim of obtaining diclofenac sodium (DFS) prolonged release dosage forms. The effects of the drug:polymer ratio and addition of Pluronic F68® to the formulations on drug content, particle size and DFS release rate were evaluated using a 22 factorial design. The DFS encapsulation efficiency (%) and the drug content varied from 40 to 70 % and from 4.5 to 13 mg/100 mg, respectively. The mean particle diameter varied from 720 to 850 μm. The addition of Pluronic F68® to the formulations led to an increase in the roughness of the surface. The differential scanning calorimetry (DSC) and infrared spectroscopy (FTIR) studies indicated the presence of Pluronic F68® in the particles. The statistical analysis revealed that the drug content and the release rate of DFS were significantly increased when 1:4 drug:polymer ratio and Pluronic F68® was used to prepare the microspheres. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Medeiros, D. C. D. E. A. (2011). Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres. http://sedici.unlp.edu.ar/handle/10915/8376

MLA

Medeiros, Daniela C. de et al. "Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres." 2011. http://sedici.unlp.edu.ar/handle/10915/8376.

Chicago

Medeiros, Daniela C. de et al. 2011. "Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres.". http://sedici.unlp.edu.ar/handle/10915/8376.

Harvard

Medeiros, D. C. D. E. A. 2011, Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8376 [Accessed 10 Aug. 2026].

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Title
Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
Author / contributors
Medeiros, Daniela C. de et al
Publisher
SEDICI UNLP
Publication year
2011
Language
English

Subjects

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Farmacia; Microesferas; Diclofenaco; Sistemas de Liberación de Medicamentos
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