News Help Institutional access
Back to results
Bibliographic record · Consultation and access
Artículo

Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release

Pandit, Jayant K. et al · SEDICI UNLP · 2012

Open-access full text
Quick overview. Review the resource’s basic details, then access the content using the main button. This page shows only the information needed to identify, cite, and open the work.
Author / responsible party
Pandit, Jayant K. et al
Publisher
SEDICI UNLP
Year
2012
Language
English

Resource access

Open the content from the main option or choose another available source.

SEDICI UNLP SEDICI UNLP OAI-PMH
Entrar por SEDICI UNLP
Main access

Open-access full text

Texto completo identificado como acceso abierto.
Open text

Summary

Descripción general del contenido del recurso.

The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were prepared in one step without using any chemical crosslinker. Briefly, an emulsion of gellan gum (GG) with gelucire 39/01 and 50/13 containing CaCO<sub>3</sub> and drug was extruded dropwise into low molecular weight chitosan (LMCH) solution. Beads formed instantaneously were cured for 15 min at elevated temperature (37 °C). Prepared beads showed excellent buoyancy along with significantly improved encapsulation efficiency and sustained release of metronidazole when compared to floating gellan-chitosan PEC beads prepared in the similar manner but without gelucires. Experimental data obtained from the present investigation showed that floating emulsion PEC beads may form a potential stomach site specific drug delivery system for the delivery of highly water soluble drugs with an absorption window in the upper gastrointestinal tract. Colegio de Farmacéuticos de la Provincia de Buenos Aires

How to cite

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

Pandit, J. K. E. A. (2012). Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release. http://sedici.unlp.edu.ar/handle/10915/8426

MLA

Pandit, Jayant K. et al. "Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release." 2012. http://sedici.unlp.edu.ar/handle/10915/8426.

Chicago

Pandit, Jayant K. et al. 2012. "Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release.". http://sedici.unlp.edu.ar/handle/10915/8426.

Harvard

Pandit, J. K. E. A. 2012, Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8426 [Accessed 6 Aug. 2026].

Share and print

Save the record, copy its permanent link, or print it as a PDF.

Export reference

You can export the record in common formats for use in a reference manager.

RIS BibTeX

Resource details

Bibliographic information to help confirm that this is the correct material.

Title
Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
Author / contributors
Pandit, Jayant K. et al
Publisher
SEDICI UNLP
Publication year
2012
Language
English

Subjects

Explore related resources through these subjects.

Farmacia; Quitosana; complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex; Glicerol; Metronidazol; Sistemas de Liberación de Medicamentos
Copied