News Help Institutional access
Back to results
Bibliographic record · Consultation and access
Artículo

Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug

Tan, Yvonne T.F. et al · SEDICI UNLP · 2012

Open-access full text
Quick overview. Review the resource’s basic details, then access the content using the main button. This page shows only the information needed to identify, cite, and open the work.
Author / responsible party
Tan, Yvonne T.F. et al
Publisher
SEDICI UNLP
Year
2012
Language
English

Resource access

Open the content from the main option or choose another available source.

SEDICI UNLP SEDICI UNLP OAI-PMH
Entrar por SEDICI UNLP
Main access

Open-access full text

Texto completo identificado como acceso abierto.
Open text

Summary

Descripción general del contenido del recurso.

The aim of this study was to investigate the potential of a polyethylene glycol-phosphatidylethanolamine conjugate (PEG<sub>2000</sub> -DSPE) to solubilize budesonide (BUD) for pulmonary delivery. The BUD-strictly stabilized phospholipid nanomicelles (SSMs) were prepared using the coprecipitation and reconstitution method and the physicochemical characteristics and pharmacodynamic duration of the BUD-SSMs were determined. The solubility of BUD was highly improved by at least 52 times its intrinsic solubility. The hydrodynamic particle size and zeta potential were 14.31 ± 1.40 nm and -46.61 ± 2.94 mV, respectively. The in vitro release of BUD from SSMs was completed within 6 days. Aerosolization of rehydrated BUD-SSMs with different nebulizers showed superior and significant aerodynamic characterizations compared to Pulmicort Respules® (PR). An in vivo study showed a significant reduction in the inflammatory cell counts of bronchoalveolar lavage fluid compared to PR. As a result, this study suggested that PEG<sub>2000</sub> -DSPE is a promising candidate as a budesonide carrier for pulmonary delivery. Colegio de Farmacéuticos de la Provincia de Buenos Aires

How to cite

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

Tan, Y. T. E. A. (2012). Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug. http://sedici.unlp.edu.ar/handle/10915/8431

MLA

Tan, Yvonne T.F. et al. "Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug." 2012. http://sedici.unlp.edu.ar/handle/10915/8431.

Chicago

Tan, Yvonne T.F. et al. 2012. "Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug.". http://sedici.unlp.edu.ar/handle/10915/8431.

Harvard

Tan, Y. T. E. A. 2012, Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8431 [Accessed 8 Aug. 2026].

Share and print

Save the record, copy its permanent link, or print it as a PDF.

Export reference

You can export the record in common formats for use in a reference manager.

RIS BibTeX

Resource details

Bibliographic information to help confirm that this is the correct material.

Title
Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug
Author / contributors
Tan, Yvonne T.F. et al
Publisher
SEDICI UNLP
Publication year
2012
Language
English

Subjects

Explore related resources through these subjects.

Farmacia; Micelas; nebulizer; pharmacodynamic; pulmonary delivery; Budesonida
Copied