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Multiple imputation using chained equations: Issues and guidance for practice

Ian R. White; Patrick Royston; Angela Wood · Statistics in Medicine · 2010

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Multiple imputation by chained equations is a flexible and practical approach to handling missing data. We describe the principles of the method and show how to impute categorical and quantitative variables, including skewed variables. We give guidance on how to specify the imputation model and how many imputations are needed. We describe the practical analysis of multiply imputed data, including model building and model checking. We stress the limitations of the method and discuss the possible pitfalls. We illustrate the ideas using a data set in mental health, giving Stata code fragments.

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APA 7

White, I. R, Royston, P, & Wood, A. (2010). Multiple imputation using chained equations: Issues and guidance for practice. https://doi.org/10.1002/sim.4067

MLA

White, Ian R, et al. "Multiple imputation using chained equations: Issues and guidance for practice." 2010. https://doi.org/10.1002/sim.4067.

Chicago

White, Ian R, Patrick Royston, and Angela Wood. 2010. "Multiple imputation using chained equations: Issues and guidance for practice.". https://doi.org/10.1002/sim.4067.

Harvard

White, I. R, Royston, P. and Wood, A. 2010, Multiple imputation using chained equations: Issues and guidance for practice, Statistics in Medicine, available at: https://doi.org/10.1002/sim.4067 [Accessed 7 Aug. 2026].

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Title
Multiple imputation using chained equations: Issues and guidance for practice
Author / contributors
Ian R. White; Patrick Royston; Angela Wood
Publisher
Statistics in Medicine
Publication year
2010
Language
English

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