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Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands

I.L.D. Silva et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2014

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Author / responsible party
I.L.D. Silva et al
Publisher
Universidade Federal de Minas Gerais, Escola de Veterinária
Year
2014
ISSN
1678-4162
ISSN
1678-4162
Language
English
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Biomolecular evidence has shown that ductal carcinoma in situ (DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situ in canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that aggressive tumors tend to lose the expression of EGFR and HER2 simultaneously. The loss of the expression of these markers may be related to the process of neoplastic progression in canine mammary tumors.

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APA 7

al, I. S. E. (2014). Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands. https://doi.org/10.1590/1678-41626128

MLA

al, I.L.D. Silva et. "Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands." 2014. https://doi.org/10.1590/1678-41626128.

Chicago

al, I.L.D. Silva et. 2014. "Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands.". https://doi.org/10.1590/1678-41626128.

Harvard

al, I. S. E. 2014, Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands, Universidade Federal de Minas Gerais, Escola de Veterinária, available at: https://doi.org/10.1590/1678-41626128 [Accessed 7 Aug. 2026].

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Title
Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands
Author / contributors
I.L.D. Silva et al
Publisher
Universidade Federal de Minas Gerais, Escola de Veterinária
Publication year
2014
ISSN
1678-4162
ISSN
1678-4162
Language
English

Subjects

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cão; neoplasia; imuno-histoquímica; EGFR; CerbB-2
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