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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

Avshalom Caspi; Karen Sugden; Terrie E. Moffitt; Alan Taylor; Ian Craig; HonaLee Harrington; Joseph L. McClay; Jonathan Mill · Science · 2003

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Author / responsible party
Avshalom Caspi; Karen Sugden; Terrie E. Moffitt; Alan Taylor; Ian Craig; HonaLee Harrington; Joseph L. McClay; Jonathan Mill
Publisher
Science
Year
2003
Language
English

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In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

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APA 7

Caspi, A, Sugden, K, Moffitt, T. E, Taylor, A, Craig, I, Harrington, H, McClay, J. L, & Mill, J. (2003). Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene. https://doi.org/10.1126/science.1083968

MLA

Caspi, Avshalom, et al. "Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene." 2003. https://doi.org/10.1126/science.1083968.

Chicago

Caspi, Avshalom, Karen Sugden, Terrie E. Moffitt, Alan Taylor, Ian Craig, HonaLee Harrington, Joseph L. McClay, and Jonathan Mill. 2003. "Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene.". https://doi.org/10.1126/science.1083968.

Harvard

Caspi, A. et al. 2003, Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene, Science, available at: https://doi.org/10.1126/science.1083968 [Accessed 10 Aug. 2026].

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Title
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Author / contributors
Avshalom Caspi; Karen Sugden; Terrie E. Moffitt; Alan Taylor; Ian Craig; HonaLee Harrington; Joseph L. McClay; Jonathan Mill
Publisher
Science
Publication year
2003
Language
English

Subjects

Explore related resources through these subjects.

Serotonin transporter; Moderation; Depression (economics); Allele; Polymorphism (computer science); Gene; Genetics; Psychology; Longitudinal study; Biology; Medicine; Genotype
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