Central diabetes insipidus in a young dog - case report

ABSTRACT This work reports a case of an 11-month-old spayed, female mongrel with polyuria, polydipsia, polakiuria and nocturia. Serum biochemistry (alkaline phosphatase, ALT, urea, creatinine, GGT, globulins, triglycerides, cholesterol, total proteins), hemogram, urinalysis and abdominal ultrasound were requested. Blood exams were within the normal range and the urinalysis resulted in urine density of 1.009. Therefore, SDMA, bile acids, bilirubin (total and fractions), urinary protein: creatinine ratio, urinary GGT, Antinuclear Antibodies (ANA), and a new urinalysis were performed. All the measured parameters were within the normal range, except for the urine density of 1.010, suggesting Diabetes Insipidus. The 12-hour water deprivation test associated with desmopressin acetate revealed an increase in urine density to 1.028 and 1.029, one and two hours after administration of the medicine. Treatment was initiated with 3 drops of DDAVP daily in each eye, resulting in a slight improvement in clinical signs, and the dose was increased to 4 drops daily, resulting in the disappearance of the clinical signs and decreased the daily water intake by over 50%.