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The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis

Andrea Moura Rodrigues Maciel da Fonseca et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2016

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Author / responsible party
Andrea Moura Rodrigues Maciel da Fonseca et al
Publisher
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Year
2016
ISSN
0100-7203
ISSN
0100-7203
Language
English
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A FEBRASGO e o Novo Ano

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Abstract The overactive bladder (OAB) has a significant negative impact on the quality of life of patients. Antimuscarinics have become the pharmacological treatment of choice for this condition. The objective of this systematic review and meta-analysis is to examine the evidence from randomized clinical trials about the outcomes of the antimuscarinic drugs available in Brazil on OABs. We searched MEDLINE and the Cochrane Central Register of Controlled Trials from the inception of these databases through to September 2015. The primary outcome measures were the mean decrease in urge urinary incontinence episodes and the mean decrease in the frequency of micturition. The results suggest that there is a moderate to high amount of evidence supporting the benefit of using anticholinergic drugs in alleviating OAB symptoms when compared with placebo. It is still not clear whether any of the specific drugs that are available in Brazil offer advantages over the others. These drugs are associated with adverse effects (dry mouth and constipation), although they are not related to an increase in the number of withdrawals.

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APA 7

al, A. M. R. M. D. F. E. (2016). The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis. https://doi.org/10.1055/s-0036-1594289

MLA

al, Andrea Moura Rodrigues Maciel da Fonseca et. "The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis." 2016. https://doi.org/10.1055/s-0036-1594289.

Chicago

al, Andrea Moura Rodrigues Maciel da Fonseca et. 2016. "The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis.". https://doi.org/10.1055/s-0036-1594289.

Harvard

al, A. M. R. M. D. F. E. 2016, The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis, Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, available at: https://doi.org/10.1055/s-0036-1594289 [Accessed 9 Aug. 2026].

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Title
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis
Author / contributors
Andrea Moura Rodrigues Maciel da Fonseca et al
Publisher
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Publication year
2016
ISSN
0100-7203
ISSN
0100-7203
Language
English

Subjects

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overactive bladder; urge incontinence; urinary frequency and antimuscarinics
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