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A Long-term Estrogen Deficiency in Ovariectomized Mice is Associated with Disturbances in Fatty Acid Oxidation and Oxidative Stress

Monique Cristine de Oliveira et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2018

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Author / responsible party
Monique Cristine de Oliveira et al
Publisher
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Year
2018
ISSN
0100-7203
ISSN
0100-7203
Language
English
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A FEBRASGO e o Novo Ano

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Abstract Objective The aim of this work was to evaluate the changes caused by estrogen deficiency in lipid metabolism. Methods This study encompassed direct measurements of plasma biochemical analyses, liver lipid contents, and assessments of the mitochondrial β-oxidation capacity as well as an evaluation of the liver redox status in an animal model of estrogen deficiency. Results When compared with control mice, the livers of ovariectomized (OVX) mice presented considerable accretions in their lipid contents, which were accompanied by increased levels of lipid peroxidation in liver homogenates andmitochondria from OVX groups and decreased reduced glutathione (GSH) contents. In isolated mitochondria, estrogen deficiency inhibited mitochondrial β-oxidation of fatty acids irrespective of their chain length. The liver mitochondrial and peroxisomal H2O2 generations in OVX mice were increased. Additionally, the activities of all antioxidant enzymes assessed were decreased. Conclusion These data provide one potential explanation for the increased susceptibility to metabolic diseases observed after menopause.

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APA 7

al, M. C. D. O. E. (2018). A Long-term Estrogen Deficiency in Ovariectomized Mice is Associated with Disturbances in Fatty Acid Oxidation and Oxidative Stress. https://doi.org/10.1055/s-0038-1666856

MLA

al, Monique Cristine de Oliveira et. "A Long-term Estrogen Deficiency in Ovariectomized Mice is Associated with Disturbances in Fatty Acid Oxidation and Oxidative Stress." 2018. https://doi.org/10.1055/s-0038-1666856.

Chicago

al, Monique Cristine de Oliveira et. 2018. "A Long-term Estrogen Deficiency in Ovariectomized Mice is Associated with Disturbances in Fatty Acid Oxidation and Oxidative Stress.". https://doi.org/10.1055/s-0038-1666856.

Harvard

al, M. C. D. O. E. 2018, A Long-term Estrogen Deficiency in Ovariectomized Mice is Associated with Disturbances in Fatty Acid Oxidation and Oxidative Stress, Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, available at: https://doi.org/10.1055/s-0038-1666856 [Accessed 5 Aug. 2026].

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Title
A Long-term Estrogen Deficiency in Ovariectomized Mice is Associated with Disturbances in Fatty Acid Oxidation and Oxidative Stress
Author / contributors
Monique Cristine de Oliveira et al
Publisher
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Publication year
2018
ISSN
0100-7203
ISSN
0100-7203
Language
English

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mitochondria; non-alcoholic fatty liver disease; obesity; ovariectomy; reactive oxygen species
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