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A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl

Matos, Orleane R. et al · SEDICI UNLP · 2012

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Author / responsible party
Matos, Orleane R. et al
Publisher
SEDICI UNLP
Year
2012
Language
English

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A new, simple, precise, sensitive and low-cost spectrophotometric method for methyldopa (MTD) determination in pharmaceutical preparations is described. This method is based on the reduction reaction of the free radical, 2,2-diphenyil-picrylhydrazyl (DPPH•), by the MTD. Absorbance of the resulting product is measured at 515 nm. Beer's Law is obeyed in a concentration range of 3.36 × 10<sup>-6</sup> a 1.34 × 10<sup>-5</sup> mol/L methyldopa with a good correlation coefficient (r = 0.9971). No interference was observed from common excipients in formulations. The results show a simple, accurate and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95 % confidence level. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Matos, O. R. E. A. (2012). A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl. http://sedici.unlp.edu.ar/handle/10915/18047

MLA

Matos, Orleane R. et al. "A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl." 2012. http://sedici.unlp.edu.ar/handle/10915/18047.

Chicago

Matos, Orleane R. et al. 2012. "A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl.". http://sedici.unlp.edu.ar/handle/10915/18047.

Harvard

Matos, O. R. E. A. 2012, A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/18047 [Accessed 8 Aug. 2026].

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Title
A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
Author / contributors
Matos, Orleane R. et al
Publisher
SEDICI UNLP
Publication year
2012
Language
English

Subjects

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Farmacia; Metildopa; 2 2-diphenyil-picrylhydrazyl; pharmaceutical formulations; Espectrofotometría
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