Biotransformation of Oleanolic Acid by Penicillium melinii

Liu, Dailin et al · SEDICI UNLP · 2012

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Liu, Dailin et al

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SEDICI UNLP

Year

2012

Language

English

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Oleanolic acid (1) is a bioactive compound widely distributed in nature. Microbial transformation is an effective way to alter the structures of compounds. The result of biotransformation of oleanolic acid was carried out in this paper. Four transform products (2-5) from 1 by Penicillium melinii were isolated. Their structures were established by spectral data interpretation as 21β-hydroxyoleanolic acid (2), 21α-hydroxyoleanolic acid (3), canthic acid (4), and 7α, 21β-dihydroxyl oleanolic acid (5). Compound 3 had stronger antibacterial activities against MRSA and Staphylococcus aureus than the substrate. It was reported for the first time that the hydroxylation products of oleanic acid can be obtained by biotransformation using incubation with Penicillium melinii. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Liu, D. E. A. (2012). Biotransformation of Oleanolic Acid by Penicillium melinii. http://sedici.unlp.edu.ar/handle/10915/18261

MLA

Liu, Dailin et al. "Biotransformation of Oleanolic Acid by Penicillium melinii." 2012. http://sedici.unlp.edu.ar/handle/10915/18261.

Chicago

Liu, Dailin et al. 2012. "Biotransformation of Oleanolic Acid by Penicillium melinii.". http://sedici.unlp.edu.ar/handle/10915/18261.

Harvard

Liu, D. E. A. 2012, Biotransformation of Oleanolic Acid by Penicillium melinii, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/18261 [Accessed 9 Aug. 2026].

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Title: Biotransformation of Oleanolic Acid by Penicillium melinii

Author / contributors: Liu, Dailin et al

Publisher: SEDICI UNLP

Publication year: 2012

Language: English

Subjects

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Farmacia; Farmacología; antibacterial activity; biotransformation; oleanolic acid; penicillium melinii; triterpenoid; Penicilinas; Ácido Oleanólico