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A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions

Santos, Sara S. et al · SEDICI UNLP · 2012

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A simple and fast HPLC method has been validated for the determination of clotrimazole in nanocapsule suspensions prepared from an acrylic polymer, Eudragit RS100®. Chromatographic runs were performed on a RP C18 column with a mobile phase comprising methanol and water (90:10, v/v) at a flow rate of 1.0 mL/min with UV detection at 229 nm. The method was shown to be specific, linear (r = 0.9987), precise and accurate in a concentration range of 2.0-10.0 μg/mL. The proposed method can be successfully used to quantify clotrimazole content in acrylic nanocapsule formulations, as well as to estimate drug encapsulation efficiency. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Santos, S. S. E. A. (2012). A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions. http://sedici.unlp.edu.ar/handle/10915/18276

MLA

Santos, Sara S. et al. "A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions." 2012. http://sedici.unlp.edu.ar/handle/10915/18276.

Chicago

Santos, Sara S. et al. 2012. "A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions.". http://sedici.unlp.edu.ar/handle/10915/18276.

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Santos, S. S. E. A. 2012, A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/18276 [Accessed 8 Aug. 2026].

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Title
A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
Author / contributors
Santos, Sara S. et al
Publisher
SEDICI UNLP
Publication year
2012
Language
English

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