Exploring the Landscape of Mental Health: Progress in Psychosis Treatment and the Therapeutic Potential of Phytochemicals

Mental illness is a critical aspect of human health that significantly affects individuals' emotional and psychological well-being. The present study focused on the “Current status of mental health which highlights both advancements and persistent challenges.” About 10% of people worldwide suffer from psychosis, a mental illness characterized by severe distortions in cognition, behavior, perception (delusions and hallucinations), and the ability to identify reality. The growing interest in natural remedies for mental health issues in recent years is indicative of a move toward more comprehensive methods of treating ailments including stress, anxiety, and depression. Numerous genetic, nutritional, microbial, and environmental variables are involved in this complex illness. However, several conditions are included under psychotic illnesses. Although they are pharmacologically categorized as dopamine receptor antagonists, many of them also act on other targets, such as 5-hydroxytryptamine (5-HT) receptors, which may contribute to some of their therapeutic efficacy. The activation of the immune system, neuro-inflammation, endocannabinoid receptors, neurotransmission, cell signaling pathways, and oxidative stress status are all changed and modified by these phytochemicals. Most phytochemicals with anti-schizophrenic properties include flavonoids, alkaloids, terpenoids, polypropanoids, lactones, and glycosides. Keywords: Psychosis, Phytochemicals, Medications, Receptors, Schizophrenia, Disease, Anti-psychotics