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A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen

Barfield, C. A. et al · Institute Of Electrical And Electronics Engineers · 2011

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Author / responsible party
Barfield, C. A. et al
Publisher
Institute Of Electrical And Electronics Engineers
Year
2011
ISSN
0018-9294
ISSN
0018-9294
Language
English

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Improved diagnostic tests for Chagas disease are urgently needed. A new lateral flow rapid test for Chagas disease is under development at PATH, in collaboration with Laboratorio Lemos of Argentina, which utilizes a recombinant antigen for detection of antibodies to Trypanosoma cruzi. To evaluate the performance of this test, 375 earlier characterized serum specimens from a region where Chagas is endemic were tested using a reference test (the Ortho T. cruzi ELISA, Johnson & Johnson), a commercially available rapid test (Chagas STAT-PAK, Chembio), and the PATH-Lemos rapid test. Compared to the composite reference tests, the PATH-Lemos rapid test demonstrated an optimal sensitivity of 99.5% and specificity of 96.8%, while the Chagas STAT-PAK demonstrated a sensitivity of 95.3% and specificity of 99.5%. These results indicate that the PATH-Lemos rapid test shows promise as an improved and reliable tool for screening and diagnosis of Chagas disease. Fil: Barfield, C. A.. PATH; Estados Unidos Fil: Barney, R. S.. PATH; Estados Unidos

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APA 7

Barfield, C. A. E. A. (2011). A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen. http://hdl.handle.net/11336/13720

MLA

Barfield, C. A. et al. "A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen." 2011. http://hdl.handle.net/11336/13720.

Chicago

Barfield, C. A. et al. 2011. "A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen.". http://hdl.handle.net/11336/13720.

Harvard

Barfield, C. A. E. A. 2011, A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen, Institute Of Electrical And Electronics Engineers, available at: http://hdl.handle.net/11336/13720 [Accessed 10 Aug. 2026].

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Title
A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen
Author / contributors
Barfield, C. A. et al
Publisher
Institute Of Electrical And Electronics Engineers
Publication year
2011
ISSN
0018-9294
ISSN
0018-9294
Language
English

Subjects

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Chagas Disease; Immunoassay; Medical Diagnosis; Point of Care; https://purl.org/becyt/ford/3.3; https://purl.org/becyt/ford/3
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