News Help Institutional access
Back to results
Bibliographic record · Consultation and access
Artículo

Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads

Lapponi, María José et al · American Institute of Chemical Engineers · 2019

Open-access full text
Quick overview. Review the resource’s basic details, then access the content using the main button. This page shows only the information needed to identify, cite, and open the work.
Author / responsible party
Lapponi, María José et al
Publisher
American Institute of Chemical Engineers
Year
2019
ISSN
8756-7938
ISSN
8756-7938
Language
English

Resource access

Open the content from the main option or choose another available source.

CONICET Digital CONICET Digital OAI-PMH
Entrar por CONICET Digital
Main access

Open-access full text

Texto completo identificado como acceso abierto.
Open text

Summary

Descripción general del contenido del recurso.

Cladribine is a nucleoside analogue widely used in the pharmaceutical industry for the treatment of several neoplasms, including hairy-cell leukemia among others. This compound has also shown efficacy in the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In this work, a green bioprocess for cladribine biosynthesis using immobilized Arthrobacter oxydans was developed. The microorganism was stabilized by entrapment immobilization in the natural matrix alginate. Different reaction parameters were optimized obtaining a biocatalyst able to achieve cladribine bioconversion values close to 85% after 1 hr, the shortest reaction times reported so far. The developed bioprocess was successfully scaled-up reaching a productivity of 138 mg L−1 hr−1. Also, the biocatalyst was stable for 5 months in storage and in 96 hr at operational conditions. Fil: Lapponi, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina Fil: Britos, Claudia Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina

How to cite

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

Lapponi, M. J. E. A. (2019). Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads. https://nodovox.com/record.php?id=740586

MLA

Lapponi, María José et al. "Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads." 2019. https://nodovox.com/record.php?id=740586.

Chicago

Lapponi, María José et al. 2019. "Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads.". https://nodovox.com/record.php?id=740586.

Harvard

Lapponi, M. J. E. A. 2019, Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads, American Institute of Chemical Engineers, available at: https://nodovox.com/record.php?id=740586 [Accessed 9 Aug. 2026].

Share and print

Save the record, copy its permanent link, or print it as a PDF.

Export reference

You can export the record in common formats for use in a reference manager.

RIS BibTeX

Resource details

Bibliographic information to help confirm that this is the correct material.

Title
Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads
Author / contributors
Lapponi, María José et al
Publisher
American Institute of Chemical Engineers
Publication year
2019
ISSN
8756-7938
ISSN
8756-7938
Language
English

Subjects

Explore related resources through these subjects.

2-CHLORODEOXYADENOSINE; ANTITUMOR AGENT; BIOTRANSFORMATIONS; GREEN CHEMISTRY; WHOLE-CELL IMMOBILIZATION; https://purl.org/becyt/ford/2.9; https://purl.org/becyt/ford/2
Copied