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Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads

Lapponi, María José et al · American Institute of Chemical Engineers · 2019

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Author / responsible party
Lapponi, María José et al
Publisher
American Institute of Chemical Engineers
Year
2019
ISSN
8756-7938
ISSN
8756-7938
Language
English

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Cladribine is a nucleoside analogue widely used in the pharmaceutical industry for the treatment of several neoplasms, including hairy-cell leukemia among others. This compound has also shown efficacy in the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In this work, a green bioprocess for cladribine biosynthesis using immobilized Arthrobacter oxydans was developed. The microorganism was stabilized by entrapment immobilization in the natural matrix alginate. Different reaction parameters were optimized obtaining a biocatalyst able to achieve cladribine bioconversion values close to 85% after 1 hr, the shortest reaction times reported so far. The developed bioprocess was successfully scaled-up reaching a productivity of 138 mg L−1 hr−1. Also, the biocatalyst was stable for 5 months in storage and in 96 hr at operational conditions. Fil: Lapponi, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina Fil: Britos, Claudia Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina

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APA 7

Lapponi, M. J. E. A. (2019). Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads. http://hdl.handle.net/11336/163379

MLA

Lapponi, María José et al. "Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads." 2019. http://hdl.handle.net/11336/163379.

Chicago

Lapponi, María José et al. 2019. "Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads.". http://hdl.handle.net/11336/163379.

Harvard

Lapponi, M. J. E. A. 2019, Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads, American Institute of Chemical Engineers, available at: http://hdl.handle.net/11336/163379 [Accessed 8 Aug. 2026].

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Title
Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads
Author / contributors
Lapponi, María José et al
Publisher
American Institute of Chemical Engineers
Publication year
2019
ISSN
8756-7938
ISSN
8756-7938
Language
English

Subjects

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2-CHLORODEOXYADENOSINE; ANTITUMOR AGENT; BIOTRANSFORMATIONS; GREEN CHEMISTRY; WHOLE-CELL IMMOBILIZATION; https://purl.org/becyt/ford/2.9; https://purl.org/becyt/ford/2
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