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Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen

Toledo, Victoria et al · Taylor & Francis · 2017

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Author / responsible party
Toledo, Victoria et al
Publisher
Taylor & Francis
Year
2017
ISSN
0738-8551
ISSN
0738-8551
Language
English

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This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-enantiomer in terms of human health, the so called “chiral switch” in the pharmaceutical industry and the sustainability of biotransformations have been the driving forces to develop innovative technology to obtain dexketoprofen. In particular, the kinetic resolution of racemic ketoprofen through enantiomeric esterification and hydrolysis using lipases as biocatalysts are thoroughly revised and commented upon. In this context, the biocatalysts, acyl-acceptors (alcohols), reaction conditions, conversion, enantiomeric excess, and enantiomeric ratio among others are discussed. Moreover, the investigations concerning scaling up processes in order to obtain an optically pure enantiomer of the profen are presented. Finally, some guidelines about perspectives of the technology and research opportunities are given. Fil: Toledo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina Fil: Briand, Laura Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina

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APA 7

Toledo, V. E. A. (2017). Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen. http://hdl.handle.net/11336/46833

MLA

Toledo, Victoria et al. "Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen." 2017. http://hdl.handle.net/11336/46833.

Chicago

Toledo, Victoria et al. 2017. "Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen.". http://hdl.handle.net/11336/46833.

Harvard

Toledo, V. E. A. 2017, Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen, Taylor & Francis, available at: http://hdl.handle.net/11336/46833 [Accessed 7 Aug. 2026].

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Title
Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen
Author / contributors
Toledo, Victoria et al
Publisher
Taylor & Francis
Publication year
2017
ISSN
0738-8551
ISSN
0738-8551
Language
English

Subjects

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Ketoprofen; Kinetic Resolution; Esterification; Hydrolysis; Lipases; Biocatalysis; Dexketoprofen; https://purl.org/becyt/ford/2.9; https://purl.org/becyt/ford/2
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