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Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone

Glisoni, Romina Julieta et al · Wiley VCH Verlag · 2014

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Author / responsible party
Glisoni, Romina Julieta et al
Publisher
Wiley VCH Verlag
Year
2014
ISSN
1639-1651
ISSN
1639-1651
Language
English

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In this work, we investigated for the first time the conjugation of gluconolactone to a poly(ethylene oxide)-poly(propylene oxide) block copolymer by a microwave-assisted ring opening reaction. The glucosylated copolymer was obtained with high yield(90%). A conjugation extent of approximately 100% was achieved within 15 min. The modification reduced the critical micellar concentration and increased the size of the micelles. The agglutination of the modified polymeric micelles by a soluble lectin that binds glucose confirmed the recognizability of the modified nanocarrier. Finally, the solubilization of darunavir, an anti-HIV protease inhibitor, showed a sharp increase of the aqueous solubility from 91 microgram/mL to 14.2 and 18.9 mg/mL for 10% w/v pristine and glucosylated polymeric micelles, respectively. Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina Fil: Sosnik, Alejandro Dario. Technion - Israel Institute of Technology; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

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APA 7

Glisoni, R. J. E. A. (2014). Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone. http://hdl.handle.net/11336/30659

MLA

Glisoni, Romina Julieta et al. "Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone." 2014. http://hdl.handle.net/11336/30659.

Chicago

Glisoni, Romina Julieta et al. 2014. "Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone.". http://hdl.handle.net/11336/30659.

Harvard

Glisoni, R. J. E. A. 2014, Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone, Wiley VCH Verlag, available at: http://hdl.handle.net/11336/30659 [Accessed 7 Aug. 2026].

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Title
Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone
Author / contributors
Glisoni, Romina Julieta et al
Publisher
Wiley VCH Verlag
Publication year
2014
ISSN
1639-1651
ISSN
1639-1651
Language
English

Subjects

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Gluconolactone; Polymeric Micelles; Darunavir; Mw Assisted Synthesis; https://purl.org/becyt/ford/2.10; https://purl.org/becyt/ford/2
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