Skin wound healing part II: from traditional cataplasm to advanced wound dressings

The first part of this review summarizes fundamental wound-healing biology andadvances a novel, integrative roadmap for developing next-generation woundtechnologies that weave together ancestral knowledges and modernbiomaterials science, analyzing recent evidence and translational opportunitiesin that direction. It also examines clinical trials, patents, regulatory issues, andepistemological challenges around medicinal plants. (DOI). This second partdelves into historical poultices and the plants used to make them,summarizing reported medicinal effects, key phytochemicals, andmechanisms for topical wound and inflammation modulation. It follows thetranslation of these materia medica into modern technologies identifyingtranslational routes and technical gaps. In addition, the review examines thevalidation of medicinal products integrated into modern technological platforms,encompassing in vitro assays, in vivo experiments, and clinical trials. The paperargues that ancestral health paradigms, rooted in ecological knowledge andcommunity practice, can complement biomedical frameworks across research,product design, and clinical use. It prioritizes respectful, participatory approachesthat conserve biodiversity and protect the intellectual and cultural rights of sourcecommunities while centering patient autonomy and psychosocial support.Finally, it calls out critical evidence gaps and proposes methodological,ethical, and regulatory standards for rigorous ethnopharmacological validationand responsible integration of traditional poultice knowledge into contemporarywound-care innovation. Fil: Romero, Amanda Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Estudios Sociales. Universidad Nacional de Tucumán. Instituto Superior de Estudios Sociales; Argentina Fil: Rodriguez, Andrea Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina