News Help Institutional access
Back to results
Bibliographic record · Consultation and access
Artículo

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

Moya Betancourt, Sara Natalia et al · MDPI · 2023

Open-access full text
Quick overview. Review the resource’s basic details, then access the content using the main button. This page shows only the information needed to identify, cite, and open the work.
Author / responsible party
Moya Betancourt, Sara Natalia et al
Publisher
MDPI
Year
2023
ISSN
1999-4923
ISSN
1999-4923
Language
English

Resource access

Open the content from the main option or choose another available source.

CONICET Digital CONICET Digital OAI-PMH
Entrar por CONICET Digital
Main access

Open-access full text

Texto completo identificado como acceso abierto.
Open text

Summary

Descripción general del contenido del recurso.

Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems. Fil: Moya Betancourt, Sara Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Cámara, Candelaria Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina

How to cite

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

Moya Betancourt, S. N. E. A. (2023). Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models. http://hdl.handle.net/11336/226665

MLA

Moya Betancourt, Sara Natalia et al. "Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models." 2023. http://hdl.handle.net/11336/226665.

Chicago

Moya Betancourt, Sara Natalia et al. 2023. "Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models.". http://hdl.handle.net/11336/226665.

Harvard

Moya Betancourt, S. N. E. A. 2023, Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models, MDPI, available at: http://hdl.handle.net/11336/226665 [Accessed 9 Aug. 2026].

Share and print

Save the record, copy its permanent link, or print it as a PDF.

Export reference

You can export the record in common formats for use in a reference manager.

RIS BibTeX

Resource details

Bibliographic information to help confirm that this is the correct material.

Title
Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models
Author / contributors
Moya Betancourt, Sara Natalia et al
Publisher
MDPI
Publication year
2023
ISSN
1999-4923
ISSN
1999-4923
Language
English

Subjects

Explore related resources through these subjects.

BIOMEMBRANE MODELS; CHITOSAN; DICLOFENAC; DIETHYL AMINO-ETHYL DEXTRAN; LANGMUIR MONOLAYER; MAGNETIC NANOPARTICLES; MAXIMUM INSERTION PRESSURE; TRIFLUPROMAZINE; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1
Copied