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Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts

Strauss, Mariana et al · Elsevier Science · 2020

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Author / responsible party
Strauss, Mariana et al
Publisher
Elsevier Science
Year
2020
ISSN
0001-706X
ISSN
0001-706X
Language
English

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The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in four independent Latin America cohorts. A total of 3,087 individuals from Latin American countries (Colombia, Bolivia, Argentina, and Peru) were studied. In all cohorts, patients were classified as seropositive for T. cruzi antigens (n= 1,963) and seronegative (n=1,124). Based on clinical evaluation, the seropositive patients, were classified as CCC (n= 900) and asymptomatic (n=1,063). No statistically significant differences in the frequency of IL6 rs1800795 between seropositive and seronegative, or between CCC and asymptomatic patients, were found. Furthermore, after the meta-analysis of these cohorts, no statistically significant differences were observed. Our results do not support a contribution of IL6 rs1800795 genetic variant in the susceptibility to the infection and the development of chronic Chagas cardiomyopathy, in the studied cohorts. Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Casares-Marfil, Desiré. Instituto de Parasitología y Biomedicina López-Neyra, Granada; España

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APA 7

Strauss, M. E. A. (2020). Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts. http://hdl.handle.net/11336/141519

MLA

Strauss, Mariana et al. "Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts." 2020. http://hdl.handle.net/11336/141519.

Chicago

Strauss, Mariana et al. 2020. "Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts.". http://hdl.handle.net/11336/141519.

Harvard

Strauss, M. E. A. 2020, Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts, Elsevier Science, available at: http://hdl.handle.net/11336/141519 [Accessed 10 Aug. 2026].

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Title
Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts
Author / contributors
Strauss, Mariana et al
Publisher
Elsevier Science
Publication year
2020
ISSN
0001-706X
ISSN
0001-706X
Language
English

Subjects

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ASSOCIATION STUDY; CHAGAS DISEASE; IL6 POLYMORPHISM; META-ANALYSIS; https://purl.org/becyt/ford/3.1; https://purl.org/becyt/ford/3; https://purl.org/becyt/ford/3.3; https://purl.org/becyt/ford/3
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