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Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis

Wang, Chien Chun et al · World Academic Publishing · 2012

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Author / responsible party
Wang, Chien Chun et al
Publisher
World Academic Publishing
Year
2012
ISSN
2303-9345
ISSN
2303-9345
Language
English

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In aqueous solutions, sildenafil presents a very low fluorescence emission and a limited linear range. In presence of a cationic surfactant hexadecyltrim ethylammonium bromide (HTAB, method A) and anionic surfactant sodium dodecyl sulfate (SDS, method B) a great fluorescence enhancement was observed and the linearity range was enlarged. These surfactants-drug interactions lead to the development of two sensitive methods for sildenafil spectrofluorimetric determination. Nature of interactions between sildenafil and surfactants were studied and different parameters which influence these associations were discussed. Sildenafil was quantitatively determined at an emission wavelength of 435 nm and 415 nm by method A and B respectively with detection limit of 0.0012 µg mL-1 and 0.0016 µg mL-1. The methods have been successfully applied to the analysis of bulk drug, tablets and herbal medicines. Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina

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APA 7

Wang, C. C. E. A. (2012). Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis. http://hdl.handle.net/11336/14483

MLA

Wang, Chien Chun et al. "Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis." 2012. http://hdl.handle.net/11336/14483.

Chicago

Wang, Chien Chun et al. 2012. "Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis.". http://hdl.handle.net/11336/14483.

Harvard

Wang, C. C. E. A. 2012, Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis, World Academic Publishing, available at: http://hdl.handle.net/11336/14483 [Accessed 7 Aug. 2026].

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Title
Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
Author / contributors
Wang, Chien Chun et al
Publisher
World Academic Publishing
Publication year
2012
ISSN
2303-9345
ISSN
2303-9345
Language
English

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PHARMACEUTICAL ANALYSIS; FLUORIMETRIC ANALYSIS; SURFACTANT; SILDENAFIL; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1
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