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Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids

Ortiz, Javier Esteban et al · Molecular Diversity Preservation International · 2012

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Author / responsible party
Ortiz, Javier Esteban et al
Publisher
Molecular Diversity Preservation International
Year
2012
ISSN
1420-3049
ISSN
1420-3049
Language
English

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The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops. Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Berkov, Strahil. Universidad de Barcelona; España

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APA 7

Ortiz, J. E. E. A. (2012). Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids. http://hdl.handle.net/11336/198703

MLA

Ortiz, Javier Esteban et al. "Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids." 2012. http://hdl.handle.net/11336/198703.

Chicago

Ortiz, Javier Esteban et al. 2012. "Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids.". http://hdl.handle.net/11336/198703.

Harvard

Ortiz, J. E. E. A. 2012, Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids, Molecular Diversity Preservation International, available at: http://hdl.handle.net/11336/198703 [Accessed 6 Aug. 2026].

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Title
Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
Author / contributors
Ortiz, Javier Esteban et al
Publisher
Molecular Diversity Preservation International
Publication year
2012
ISSN
1420-3049
ISSN
1420-3049
Language
English

Subjects

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ACETYLCHOLINESTERASE INHIBITORS; ALKALOIDS; ARGENTINIAN AMARYLLIDACEAE WILD; GALANTHAMINE; LYCORINE; TAZETTINE; https://purl.org/becyt/ford/1.4; https://purl.org/becyt/ford/1
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