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Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain

Cisternas, Carla Daniela et al · Elsevier Ireland · 2015

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Author / responsible party
Cisternas, Carla Daniela et al
Publisher
Elsevier Ireland
Year
2015
ISSN
0303-7207
ISSN
0303-7207
Language
English

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Aromatase, which converts testosterone in estradiol, is involved in the generation of brain sex dimorphisms. Here we used the "four core genotypes" mouse model, in which the effect of gonadal sex and sex chromosome complement is dissociated, to determine if sex chromosomes influence the expression of brain aromatase. The brain of 16 days old XY mouse embryos showed higher aromatase expression in the stria terminalis and the anterior amygdaloid area than the brain of XX embryos, independent of gonadal sex. Furthermore, estradiol or dihydrotestosterone increased aromatase expression in cultures of anterior amygdala neurons derived from XX embryos, but not in those derived from XY embryos. This effect was also independent of gonadal sex. The expression of other steroidogenic molecules, estrogen receptor-α and androgen receptor was not influenced by sex chromosomes. In conclusion, sex chromosomes determine sex dimorphisms in aromatase expression and regulation in the developing mouse brain. Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina Fil: Tomé, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina

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APA 7

Cisternas, C. D. E. A. (2015). Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain. https://nodovox.com/record.php?id=884399

MLA

Cisternas, Carla Daniela et al. "Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain." 2015. https://nodovox.com/record.php?id=884399.

Chicago

Cisternas, Carla Daniela et al. 2015. "Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain.". https://nodovox.com/record.php?id=884399.

Harvard

Cisternas, C. D. E. A. 2015, Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain, Elsevier Ireland, available at: https://nodovox.com/record.php?id=884399 [Accessed 9 Aug. 2026].

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Title
Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain
Author / contributors
Cisternas, Carla Daniela et al
Publisher
Elsevier Ireland
Publication year
2015
ISSN
0303-7207
ISSN
0303-7207
Language
English

Subjects

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&Quot;Four Core Genotypes&Quot;; 17Β-Estradiol; Androgen Receptor; Aromatase; Dihydrotestosterone; Estrogen Receptor; Neurosteroids; Sex Chromosomes; Sexual Differentiation; Steroidogenesis; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1
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