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Whole-Genome Random Sequencing and Assembly of <i>Haemophilus influenzae</i> Rd

Robert Fleischmann; Mark D. Adams; Owen White; Rebecca A. Clayton; Ewen F. Kirkness; Anthony R. Kerlavage; Carol J. Bult; Jean-François Tomb · Science · 1995

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Author / responsible party
Robert Fleischmann; Mark D. Adams; Owen White; Rebecca A. Clayton; Ewen F. Kirkness; Anthony R. Kerlavage; Carol J. Bult; Jean-François Tomb
Publisher
Science
Year
1995
Language
English

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An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence (1,830,137 base pairs) of the genome from the bacterium Haemophilus influenzae Rd. This approach eliminates the need for initial mapping efforts and is therefore applicable to the vast array of microbial species for which genome maps are unavailable. The H. influenzae Rd genome sequence (Genome Sequence DataBase accession number L42023) represents the only complete genome sequence from a free-living organism.

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APA 7

Fleischmann, R, Adams, M. D, White, O, Clayton, R. A, Kirkness, E. F, Kerlavage, A. R, Bult, C. J, & Tomb, J. F. (1995). Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd. https://doi.org/10.1126/science.7542800

MLA

Fleischmann, Robert, et al. "Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd." 1995. https://doi.org/10.1126/science.7542800.

Chicago

Fleischmann, Robert, Mark D. Adams, Owen White, Rebecca A. Clayton, Ewen F. Kirkness, Anthony R. Kerlavage, Carol J. Bult, and Jean-François Tomb. 1995. "Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd.". https://doi.org/10.1126/science.7542800.

Harvard

Fleischmann, R. et al. 1995, Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd, Science, available at: https://doi.org/10.1126/science.7542800 [Accessed 8 Aug. 2026].

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Title
Whole-Genome Random Sequencing and Assembly of <i>Haemophilus influenzae</i> Rd
Author / contributors
Robert Fleischmann; Mark D. Adams; Owen White; Rebecca A. Clayton; Ewen F. Kirkness; Anthony R. Kerlavage; Carol J. Bult; Jean-François Tomb
Publisher
Science
Publication year
1995
Language
English

Subjects

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Genome; Whole genome sequencing; Biology; Genetics; Haemophilus influenzae; DNA sequencing; Sequence assembly; Computational biology; Sequence (biology); Reference genome; Chromosome; Gene
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