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A sensitive and specific high performance reversed phase liquid chromatographic method was developed for quantification of citicoline monosodium (CTM) in human plasma. The active drug was isocratically eluted at a flow r...

In the present study, a simple, rapid and precise liquid chromatographic method was developed and validated for the determination of ezetimibe in its dosage form. Ezetimibe was separated in a 100 x 4.6 mm i.d., C18 colum...

In the present study, a high performance liquid chromatographic method was developed and validated for determination of chromatographic purity and stress stability of the anti-retroviral drug lamivudine. The different an...

To develop a high performance liquid chromatography method for the simultaneous determination of cortisone and cortisol in rat serum and apply it for pharmacokinetics. After addition of pirfenidone as internal standard (...

A simple HPLC method was developed to study the pharmacokinetics of tobramycin in rat after intravenous administration. The plasma samples were deproteinized with acetonitrile after addition of the internal standard, net...

Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide. It is showed that some changes of many enzymes and transporters concerned with metabolism and disposal of drug have taken ...

Gastric ulcer is one of ulcerous diseases and may result in some changes of many enzymes and transporters concerned with metabolism and disposal of drug. The pharmacokinetic of drug should be different between peptic ulc...

A new HPLC-DAD method has been developed and validated for the simultaneous analysis of five flavonoids (rutin, quercitrin, quercetin, kaempferol, and isorahamnetin) in rat plasma. Sample pretreatment consisted of a liqu...

En el presente trabajo se validó el método por HPLC para la determinación cuantitativa del fármaco d4T (I). Se comprobó que este método fue lineal (r = 0,9987) para un intervalo de 5-40 µg/mL, exacto, preciso (CV ...

Se desarrolló y validó un método rápido y simple por HPLC para la determinación de carbamacepina en plasma humano. Las condiciones cromatográficas fueron: columna C-18, fase móvil acetonitrilo:metanol:acetato de a...

Se detalla el procedimiento utilizado al aplicar el método de Larsen y West a la determinación de aminoácidos en soluciones parenterales de gran volumen. El método consiste en la derivatización de los aminoácidos c...

La Flutamida es un antiandrógeno potente usado para el tratameinto del cáncer de próstata. Se presenta aquí un método simple, sensible y seguro de cromatografía de alta resolución (HPLC) para la determinación cua...

The objective of carrying out this research work was to investigate the effect of chirality on stereospecific dissolution of omeprazole enantiomers from various marketed racemic omeprazole products. Omeprazole is used fo...

Para la determinación de oxazepan y productos de degradación en comprimidos, se utilizó una columna de fase reversa (C18) metanol-agua como fase móvil y detección a 230 nm. Como estándar interno se usó flunitrazep...

HPLC-DAD was used and validated for the simultaneous determination of five flavonoids (rutin, quercitrin, quercetin, kaempferol and isorahamnetin) in rabbit plasma. Chromatographic separation was performed on an Aglient ...

Ascaridol es un endoperóxido cíclico que constituye el principal principio farmacológicamente activo de la planta medicinal conocida popularmente como "paico" (Chenopodium ambrosioides L.). Sus infusiones y decoccione...

Se estudiaron las condiciones cromatográficas, fase estacionaria, fase móvil y flujo de elución para la determinación cuantitativa de Ranitidina (I) en presencia de sus precursores sintéticos, 1-metilamino-1-metilti...

A new sensitive, rapid and simple HPLC-DAD method has been developed and validated for simultaneous determination of captopril (CAP), hydrochlorothiazide (HCTZ) and their related compounds, captopril disulfide (CAD), chl...

A new HPLC-DAD method has been developed and validated for the simultaneous analysis of nine flavonoids (rutin, myricetin, quercitrin, quercetin, luteolin, genistein, kaempferol, apigenin, and isorhamnetin) in Ginkgo bil...

Semen Persicae was a traditional Chinese medicine for the treatment of diseases such as inflammation and hyperlipemia. Amygdalin was one of the main active ingredients of this traditional Chinese medicine. In this paper,...

El presente trabajo describe la validación de un método isocrático de HPLC destinado a la valoración cuantitativa de losartano potá- sico en tabletas y cápsulas. Fue también evaluada la estabilidad de la materia p...

A fast and simple HPLC-PDA method for rosmarinic acid quantification in Rosemary leaves powder was validated. The analyses were performed using a C18 column in isocratic conditions and detection at 254 nm. Performing the...

An ultraviolet (UV) spectrophotometric method was developed for the analysis of telithromycin, member of the ketolides, in drug substance and coated tablets. The method validation yielded good results, such as the range,...

Benzocaine (BZC) is an ester-type local anesthetic used mainly in topical, dermal and mucosal formulations. The present work consists of the development and validation of analytical methodology for evaluation of benzocai...