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Abstract Background Epilepsy in dogs and humans is associated with blood‐brain barrier (BBB) dysfunction (BBBD), which may involve dysfunction of tight junction (TJ) proteins, matrix metalloproteases, and astrocytes. I...

There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitiv...

Objective: To investigate the pharmacodynamic effects of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou (Z. jujuba, Suan Zao Ren) fermented with the fungus of Poria cocos (Schw.) Wolf (P. cocos strain) and M...

Red blood cells (RBCs), formerly viewed as mere oxygen transporters, are now acknowledged as dynamic biological entities with intricate molecular characteristics which impact their deformability, lifespan, and interactio...

Aim: To develop a cost-effective, predictive model for hypertensive disorders of pregnancy (HDP) in advanced-aged pregnant women based on demographic and lifestyle factors. Methods: A large prospective, population-based,...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...

Abstract Background Hypertension is increasingly recognised among younger adults and contributes to early cardiovascular risk, yet population-level data in this age group remain limited in many low- and middle-income cou...

ABSTRACT The aim of this study was to investigate the presence of anti-Neospora caninum antibodies in Girolando cows, in order to evaluate the association between seropositivity and reproductive disorders. Blood samples ...

BackgroundNewborn screening (NBS) with kappa-deleting recombination excision circles (KRECs) is primarily used to detect B cell lymphopenia and agammaglobulinemia as markers of inborn errors of immunity (IEIs). However, ...

Objective: The aim of the present study was to show the important effectof a uremic environmenton the development of insulin resistance and if insulin resistance might be reversible with the treatment of metabolic disord...

Mild cognitive impairment (MCI) and dementias, such as Alzheimer’s disease (AD)-induced dementia and vascular dementia, are major public health burdens. The blood-brain barrier (BBB) disruption, systemic inflammation, ...

Abstract Objectives The relationship between metabolic dysregulation and frailty remains incompletely understood. This study examines the association between metabolic dysregulation and frailty in middle-aged and older a...

Abstract Background Blood-based biomarkers could improve the precision of Alzheimer’s disease (AD) clinical diagnosis and expand access to targeted treatments. Therefore, we evaluated the diagnostic accuracy of plasma ...

Bovine herpesvirus type 4 (BoHV-4) is a gamma-herpesvirus that has been isolated from apparently asymptomatic animals and from cattle with a variety of clinical signs. The pathogenic role of BoHV-4 remains unclear and i...

Abstract Background Obesity has emerged as a major global health issue, affecting multiple organ systems. Within the central nervous system obesity causes a series of disruptions that can significantly affect neurologica...

The gut microbiota has co-evolved with its host and forms an essential component of the human body. It is acquired at birth and continues to develop alongside the host, preserving its diversity and stability throughout l...

Latar belakang: kandidiasis (kandidosis) adalah infeksi jamur yang disebabkan oleh spesies Candida biasanya Candida albicans. Faktor predisposisi yang memicu kandidiasis adalah terganggunya ekologi mulut karena antara la...

Abstract Background and objectives The under-representation of vulnerable groups in clinical trials, including persons with disabilities, could affect the applicability of trial findings to real-world public health inter...

IntroductionAccurate segmentation of retinal blood vessels is essential for the early diagnosis of ophthalmic and systemic diseases such as diabetes, hypertension, and cardiovascular disorders. However, challenges such a...

INTRODUCTION: Malva moschata L. has long been used in traditional medicine for its calming and sedative properties, indicating potential antidepressant activity. This study evaluated the antidepressant-like effects of it...

ABSTRACT A 20-year-old unneutered male poodle presented prostration, apathy, staggering gait, lack of appetite and tick infestation. The dog was diagnosed with a Sertoli cell tumor in an undescended testicle by cytologic...

ABSTRACT Background Substance use, particularly cannabis and alcohol consumption, presents a growing public health challenge in Ghana, with significant implications for both mental and physical health. While the adverse ...

Depression and burnout are linked to a higher risk for the development of cardiovascular diseases. Physical activity has the potential to enhance prognosis of cardiovascular diseases and improve depression and burnout sy...

IntroductionChronic spontaneous urticaria (CSU) is a clinical diagnosis managed according to American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) guide...