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Abstract Background Vascular disorders of the intestine (VDI) and ischemic heart disease (IHD) are linked by shared atherosclerotic risk factors including diabetes, hypertension, and smoking. Their coexistence poses a si...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

Abstract Background Vascular endothelial inflammation is a key pathological process underlying various inflammatory vascular conditions, which can lead to severe cardiovascular complications. Shexiang Tongxin Dropping Pi...

Antiphospholipid antibodies can cause recurrent thrombotic attacks in some patients. Antiphospholipid antibodies are detected in patients with autoimmune disease especially systemic lupus erythematosus, infectious, malig...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...

Globally, one major cause of morbidity and mortality is cardiovascular diseases (CVDs). The burden of cardiovascular disease among the elderly is still high and typically tends to move to nations with lower sociodemograp...

Abstract Importance The mortality benefit of lipid-lowering therapies (LLTs) in true primary prevention of cardiovascular disease (CVD) remains uncertain, in part because prior studies frequently included individuals wit...

Disorders of the vessels, that cause organ demage in Essential Hypertension (HT), may returned at early stage. In this study, vascular disorders were evaluated in 225 HT patients with a mean age of 48.1±8.6 (%77.3 of th...

The gut microbiota has co-evolved with its host and forms an essential component of the human body. It is acquired at birth and continues to develop alongside the host, preserving its diversity and stability throughout l...

Background Histologic features of pulmonary veno‐occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description. Objectives To report the ...

Inflammation-related diseases, including cardiovascular diseases, immune disorders, and infectious diseases, have high prevalence and disability rates, imposing heavy socioeconomic and healthcare burdens. Thus, elucidati...

Mild cognitive impairment (MCI) and dementias, such as Alzheimer’s disease (AD)-induced dementia and vascular dementia, are major public health burdens. The blood-brain barrier (BBB) disruption, systemic inflammation, ...

Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Gestational trophoblastic disease (GTD) includes both neoplastic and nonneoplastic disorders arising from placental trophoblastic tissue. Among tumor-like conditions, exaggerated placental site reaction (EPSR) is a rare ...

Red blood cells (RBCs), formerly viewed as mere oxygen transporters, are now acknowledged as dynamic biological entities with intricate molecular characteristics which impact their deformability, lifespan, and interactio...

POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein) secretion, and skin changes. Its pathogenesis is driven by plasma cell dyscrasia...

Coronary artery ectasia (CAE) is a vascular lesion characterized by abnormal dilation of the coronary arteries, with complex pathogenesis and diverse clinical manifestations. CAE can be classified into primary and second...

BackgroundRecurrent bacterial pneumonia accompanied by atypical systemic findings may indicate an uncharacterized inborn error of immunity (IEI). We report a 10-year-old male with recurrent pneumonias, mildly low but fun...

The activity and survival of retinal photoreceptors depend on support functions performed by the retinal pigment epithelium (RPE) and on oxygen and nutrients delivered by blood vessels in the underlying choroid. By combi...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Abstract Background Iron overload promotes atherosclerosis in mice and causes vascular dysfunction in humans with Hemochromatosis. However, data are controversial on whether systemic iron availability within physiologica...

Abstract Background Endoplasmic reticulum stress (ERS) is linked to the progression of atherosclerosis (AS). The function of ERS-related genes (ERSRGs) in AS remains ambiguous, hence, this study sought to examined their ...

Abstract Background Ankylosing spondylitis (AS) is a chronic inflammatory disorder marked by spinal ossification that leads to progressive thoracolumbar kyphosis (TLK). We previously introduced vertebral body compression...