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Since May of 1997, special meteorological observations have been made from the southern part of Mexico to Peru, as part of a research that studies the causes of rainfall variability in central America. Once the 12 pilot ...

"The emergence of mosquitoes that can avoid indoor-deployed interventions, such as treated bed nets and indoor residual spraying, threatens the mainstay of malaria control in Zambia. Furthermore, the requirement for high...

Knaus, William A. MD; Draper, Elizabeth A. RN, MS; Wagner, Douglas P. PhD; Zimmerman, Jack E. MD Author Information

Continuing his groundbreaking analysis of economic structures, Douglass North develops an analytical framework for explaining the ways in which institutions and institutional change affect the performance of economies, b...

It has long been recognized that personality test scores are influenced by non-test-relevant response determinants. Wiggins and Rumrill (1959) distinguish three approaches to this problem. Briefly, interest in the proble...

This paper shows that bank deposit contracts can provide allocations superior to those of exchange markets, offering an explanation of how banks subject to runs can attract deposits. Investors face privately observed ris...

Without a complete published description of interventions, clinicians and patients cannot reliably implement interventions that are shown to be useful, and other researchers cannot replicate or build on research findings...

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and wide...

BACKGROUND: Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. The distributed nature of biological knowledge frequently requires researchers to n...

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has p...

Agreement between two methods of clinical measurement can be quantified using the differences between observations made using the two methods on the same subjects. The 95% limits of agreement, estimated by mean differenc...

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellul...

Mixed-effects models provide a flexible and powerful tool for the analysis of grouped data, which arise in many areas as diverse as agriculture, biology, economics, manufacturing, and geophysics. Examples of grouped data...

Materias / palabras clave: Psychology; Developmental psychology; Cognitive psychology; Social psychology

Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The ...

Systematic reviews and meta-analyses have become increasingly important in health care. Clinicians read them to keep up to date with their field,1,2 and they are often used as a starting point for developing clinical pra...

Importance: There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19). Objective: To describe the clinical charac...

From the Publisher: Using a practical approach, it discusses two-level factorial and fractional factorial designs, several aspects of empirical modeling with regression techniques, focusing on response surface methodolog...

Materias / palabras clave: Schedule for Affective Disorders and Schizophrenia; Inter-rater reliability; Medical diagnosis; Psychology; Psychiatry; Clinical psychology; Schizophrenia (object-oriented programming); Anxiety; Rating scale; Test validi...

Poor reporting of research hampers assessment and makes it less useful. An international group of methodologists, researchers, and journal editors sets out guidelines to improve reports of observational studies

Materias / palabras clave: Plasmid; Transformation (genetics); Escherichia coli; Plasmid preparation; Biology; Incubation; Dithiothreitol; T-DNA Binary system; DNA; Transformation efficiency; Chemistry; Genetics

Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is no...

Materias / palabras clave: Systematic review; Checklist; Psychological intervention; Guideline; MEDLINE; Health care; Medicine; Psychology; Management science; Nursing; Pathology; Political science

Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporti...