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Materias / palabras clave: Aspirin; Mechanism (biology); Mechanism of action; Prostaglandin; Pharmacology; Chemistry; Action (physics); Medicine; Biochemistry; Physics; In vitro; Quantum mechanics

The aim of this research was to evaluate the interference of the association of different types of nutritional diet in the anti-inflammatory and analgesic activities of etoricoxib in in vivo models. The following assays ...

Phenobarbital and carbamazepine are antiepileptic drugs that act at the nervous central system by different mechanisms of action. In this work we investigated the pharmacological effects of these drugs on mouse phrenic n...

The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. T...

La población nativa del Brasil utiliza extractos fluidos, decocción e infusión de las raíces y hojas de Petiveria alliaceae L. (Phytolacaceae, guiné) ante a los más diferentes tipos de síntomas y también como sed...

Fue evaluada la actividad antileishmania in vitro de monoterpenos sintéticos contra promastigotes y amastigotes de L. (V.) panamensis y comparada con la del Glucantime®. La actividad citotóxica fue determinada contra ...

The present study investigated analgesic and some neuropharmacological effects of hydromethanolic extract of the leaves of Xanthium indicum Koenig in mice models. The analgesic activity was evaluated using hot plate ant ...

Ethanol extract and fractions from aerial parts of Eclipta alba (L.) Hassk (Asteraceae) were screened for the antibacterial and antifungal activities against different species of human pathogenic bacterial ATCC, antibiot...

The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro ...

Using a Digiscan Actimeter, many previous studies have shown that low dose caffeine (6.25- 25 mg/kg) stimulates locomotion while caffeine in high doses (100 mg/kg) depresses locomotion. This locomotor stimulatory effects...

Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atheroscl...

Doxorubicin is a well-known DNA intercalating chemotherapy drug that is widely used for treatment of different cancers. Its clinical utility is limited due to the observed genotoxic side effects on healthy cells suggesti...

The hepato- and nephro-protective effects of sea buckthorn berries (Hippophae rhamnoides L) were investigated in paracetamol-induced toxicity in animals and hypoglycemic effects in type II diabetic patients. Crude drug p...

In this study, matrix type patch formulations of flurbiprofen using certain skin permeation enhancers [isopropyl myristate (IPM), isopropyl palmitate (IPP) and Tween 80] were formulated, evaluated and compared. The cum...

Fue realizado un estudio utilizando dos líneas celulares de linfocitos y fibroblastos pulmonares, con el objeto de investigar el efecto conjunto del metotrexate (MTX) y la cloroquina (CQ) sobre el crecimiento celular ...

Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interacti...

The present study involves development and investigation of liposomal system for improving skin residence of ciclopirox olamine in cutaneous mycosis. Spherical unilamellar liposomes of ciclopirox olamine were prepared ...

Se investigó en ratas el mecanismo del efecto "anticonflicto" de la carbamazepina, empleando una pueba de Geller y Seifter modificada. El antagonista purino-receptor aminofilina (5 mg/kg) bloqueó en este paradigma el e...

Detection of the sentinel lymph node has become a mainstay of certain surgical interventions for cancer. In this sense, physiological and biochemical properties of the molecules employed for early detection of such metas...

Debido a su biodegradabilidad varios polímeros naturales, tales como los polisacáridos, han sido propuestos como excipientes adecuados para desarrollar sistemas de liberación controlada para la administración oral. E...